@article{fdi:010066867,
  title = {{M}alagasy bats shelter a considerable genetic diversity of pathogenic {L}eptospira suggesting notable host-specificity patterns},
  author = {{G}omard, {Y}. and {D}ietrich, {M}. and {W}ieseke, {N}. and {R}amasindrazana, {B}. and {L}agadec, {E}. and {G}oodman, {S}. {M}. and {D}ellagi, {K}oussay and {T}ortosa, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}athogenic {L}eptospira are the causative agents of leptospirosis, a disease of global concern with major impact in tropical regions. {D}espite the importance of this zoonosis for human health, the evolutionary and ecological drivers shaping bacterial communities in host reservoirs remain poorly investigated. {H}ere, we describe {L}eptospira communities hosted by {M}alagasy bats, composed of mostly endemic species, in order to characterize host-pathogen associations and investigate their evolutionary histories. {W}e screened 947 individual bats (representing 31 species, 18 genera and seven families) for {L}eptospira infection and subsequently genotyped positive samples using three different bacterial loci. {M}olecular identification showed that these {L}eptospira are notably diverse and include several distinct lineages mostly belonging to {L}eptospira borgpetersenii and {L}. kirschneri. {T}he exploration of the most probable host-pathogen evolutionary scenarios suggests that bacterial genetic diversity results from a combination of events related to the ecology and the evolutionary history of their hosts. {I}mportantly, based on the data set presented herein, the notable host-specificity we have uncovered, together with a lack of geographical structuration of bacterial genetic diversity, indicates that the {L}eptospira community at a given site depends on the co-occurring bat species assemblage. {T}he implications of such tight host-specificity on the epidemiology of leptospirosis are discussed.},
  keywords = {{L}eptospira ; {C}hiroptera ; {M}adagascar ; host-parasite association ; host-specificity ; co-phylogeny ; {MADAGASCAR}},
  booktitle = {},
  journal = {{F}ems {M}icrobiology {E}cology},
  volume = {92},
  numero = {4},
  pages = {fiw037 [20 p.]},
  ISSN = {0168-6496},
  year = {2016},
  DOI = {10.1093/femsec/fiw037},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066867},
}