@article{fdi:010066858,
  title = {{T}he aetiologies and impact of fever in pregnant inpatients in {V}ientiane, {L}aos},
  author = {{C}hansamouth, {V}. and {T}hammasack, {S}. and {P}hetsouvanh, {R}. and {K}eoluangkot, {V}. and {M}oore, {C}. {E}. and {B}lacksell, {S}. {D}. and {C}astonguay-{V}anier, {J}. and {D}ubot {P}{\'e}r{\`e}s, {A}udrey and {T}angkhabuanbutra, {J}. and {T}ongyoo, {N}. and {S}ouphaphonh, {P}. and {S}engvilaipaseuth, {O}. and {V}ongsouvath, {M}. and {P}hommasone, {K}. and {S}engdethka, {D}. and {S}eurbsanith, {A}. and {C}raig, {S}. {B}. and {H}ermann, {L}. and {S}trobel, {M}. and {N}ewton, {P}. {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {L}aos has the highest maternal mortality ratio in mainland {S}outheast {A}sia and a high incidence of infectious diseases. {G}lobally, malaria has been the pathogen most intensively investigated in relation to impact on pregnancy, but there has been relatively little research on the aetiology and impact of other diseases. {W}e therefore aimed to determine the causes and impact of fever in pregnant women admitted to two central hospitals in {V}ientiane {C}ity, {L}ao {PDR} ({L}aos). {M}aterials and {M}ethods {T}his hospital-based prospective study was conducted in {M}ahosot {H}ospital and the {M}other and {C}hild {H}ospital, {V}ientiane, between 2006 and 2010, with the aim to recruit 250 consenting pregnant women admitted with tympanic temperature >= 37.5 degrees {C}. {P}rimary outcome was the cause of fever and secondary outcomes were pregnancy outcomes. {S}pecific investigations (culture, antigen, molecular and serological tests) were performed to investigate causes of fever. {A}fter discharge, all pregnant women were asked to return for review and convalescence serum on day 10-14 and were monitored until delivery. {P}rinciple findings 250 pregnant women were recruited to this study between {F}ebruary 2006 and {N}ovember 2010. {F}ifty percent were pregnant for the first time. {T}heir median (range) gestational age on admission was 24 (4-43) weeks. {T}he median (range) tympanic admission temperature was 38.5 degrees {C} (37.5-40.5 degrees {C}). {F}ifteen percent of patients stated that they had taken antibiotics before admission. {H}eadache, myalgia, back pain and arthralgia were described by >60% of patients and 149 (60%) were given a laboratory diagnosis. {O}f those with confirmed diagnoses, 132 (53%) had a single disease and 17 (7%) had apparent mixed diseases. {A}mong those who had a single disease, dengue fever was the most common diagnosis, followed by pyelonephritis, scrub typhus, murine typhus and typhoid. {P}atients were also diagnosed with tuberculosis, appendicitis, {S}taphylococcus aureus septicemia, leptospirosis, {J}apanese encephalitis virus infection and {P}lasmodium falciparum malaria. {S}evere consequences, including maternal death, miscarriage, stillbirth, low birth weight and preterm birth, were found among 28 (78%) mothers with dengue fever, rickettsioses and typhoid. {C}onclusion {F}evers other than malaria, such as dengue, pyelonephritis, rickettsioses and typhoid are common causes of fever during pregnancy in the {A}sian tropics. {F}urther investigations of their impact in the community on maternal death, fetal loss, vertical transmission, low birth weight and preterm birth are needed.},
  keywords = {{LAOS}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {10},
  numero = {4},
  pages = {e0004577 [16 p.]},
  ISSN = {1935-2735},
  year = {2016},
  DOI = {10.1371/journal.pntd.0004577},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066858},
}