@article{fdi:010066838,
  title = {{A} clinical and epidemiological investigation of the first reported human infection with the zoonotic parasite {T}rypanosoma evansi in {S}outheast {A}sia},
  author = {{C}hau, {N}. {V}. {V}. and {C}hau, {L}. {B}. and {D}esquesnes, {M}. and {H}erder, {S}t{\'e}phane and {L}an, {N}. {P}. {H}. and {C}ampbell, {J}. {I}. and {C}uong, {N}. {V}. and {Y}imming, {B}. and {C}halermwong, {P}. and {J}ittapalapong, {S}. and {F}ranco, {J}. {R}. and {T}ue, {N}. {T}. and {R}abaa, {M}. {A}. and {C}arrique-{M}as, {J}. and {T}hanh, {T}. {P}. {T}. and {T}hieu, {N}. {T}. {V}. and {B}erto, {A}. and {H}oa, {N}. {T}. and {H}oang, {N}. {V}. {M}. and {T}u, {N}. {C}. and {C}huyen, {N}. {K}. and {W}ills, {B}. and {H}ien, {T}. {T}. and {T}hwaites, {G}. {E}. and {Y}acoub, {S}. and {B}aker, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}rypanosoma is a genus of unicellular parasitic flagellate protozoa. {T}rypanosoma brucei species and {T}rypanosoma cruzi are the major agents of human trypanosomiasis; other {T}rypanosoma species can cause human disease, but are rare. {I}n {M}arch 2015, a 38-year-old woman presented to a healthcare facility in southern {V}ietnam with fever, headache, and arthralgia. {M}icroscopic examination of blood revealed infection with {T}rypanosoma. {M}ethods. {M}icroscopic observation, polymerase chain reaction ({PCR}) amplification of blood samples, and serological testing were performed to identify the infecting species. {T}he patient's blood was screened for the trypanocidal protein apolipoprotein {L}1 ({APOL}1), and a field investigation was performed to identify the zoonotic source. {R}esults. {PCR} amplification and serological testing identified the infecting species as {T}rypanosoma evansi. {D}espite relapsing 6 weeks after completing amphotericin {B} therapy, the patient made a complete recovery after 5 weeks of suramin. {T}he patient was found to have 2 wild-type {APOL}1 alleles and a normal serum {APOL}1 concentration. {A}fter responsive animal sampling in the presumed location of exposure, cattle and/or buffalo were determined to be the most likely source of the infection, with 14 of 30 (47%) animal blood samples testing {PCR} positive for {T}. evansi. {C}onclusions. {W}e report the first laboratory-confirmed case of {T}. evansi in a previously healthy individual without {APOL}1 deficiency, potentially contracted via a wound while butchering raw beef, and successfully treated with suramin. {A} linked epidemiological investigation revealed widespread and previously unidentified burden of {T}. evansi in local cattle, highlighting the need for surveillance of this infection in animals and the possibility of further human cases.},
  keywords = {{V}ietnam ; zoonosis ; {T}rypanosoma evansi ; case investigation ; emerging ; infections ; {VIET} {NAM}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {62},
  numero = {8},
  pages = {1002--1008},
  ISSN = {1058-4838},
  year = {2016},
  DOI = {10.1093/cid/ciw052},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066838},
}