Publications des scientifiques de l'IRD

Melade J., Wieseke N., Ramasindrazana B., Flores O., Lagadec E., Gomard Y., Goodman S. M., Dellagi Koussay, Pascalis Hervé. (2016). An eco-epidemiological study of Morbilli-related paramyxovirus infection in Madagascar bats reveals host-switching as the dominant macro-evolutionary mechanism. Scientific Reports - Nature, 6, p. art. 23752 [12 p.]. ISSN 2045-2322.

Titre du document
An eco-epidemiological study of Morbilli-related paramyxovirus infection in Madagascar bats reveals host-switching as the dominant macro-evolutionary mechanism
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000373772300001
Auteurs
Melade J., Wieseke N., Ramasindrazana B., Flores O., Lagadec E., Gomard Y., Goodman S. M., Dellagi Koussay, Pascalis Hervé
Source
Scientific Reports - Nature, 2016, 6, p. art. 23752 [12 p.] ISSN 2045-2322
An eco-epidemiological investigation was carried out on Madagascar bat communities to better understand the evolutionary mechanisms and environmental factors that affect virus transmission among bat species in closely related members of the genus Morbillivirus, currently referred to as Unclassified Morbilli-related paramyxoviruses (UMRVs). A total of 947 bats were investigated originating from 52 capture sites (22 caves, 18 buildings, and 12 outdoor sites) distributed over different bioclimatic zones of the island. Using RT-PCR targeting the L-polymerase gene of the Paramyxoviridae family, we found that 10.5% of sampled bats were infected, representing six out of seven families and 15 out of 31 species analyzed. Univariate analysis indicates that both abiotic and biotic factors may promote viral infection. Using generalized linear modeling of UMRV infection overlaid on biotic and abiotic variables, we demonstrate that sympatric occurrence of bats is a major factor for virus transmission. Phylogenetic analyses revealed that all paramyxoviruses infecting Malagasy bats are UMRVs and showed little host specificity. Analyses using the maximum parsimony reconciliation tool CoRe-PA, indicate that host-switching, rather than co-speciation, is the dominant macro-evolutionary mechanism of UMRVs among Malagasy bats.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde animal [080]
Description Géographique
MADAGASCAR
Localisation
Fonds IRD [F B010066782]
Identifiant IRD
fdi:010066782
Contact