@article{fdi:010066767,
  title = {{R}isk of congenital cytomegalovirus infection among {HIV}-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy},
  author = {{G}antt, {S}. and {L}eister, {E}. and {J}acobsen, {D}. {L}. and {B}oucoiran, {I}. and {H}uang, {M}. {L}. and {J}erome, {K}. {R}. and {J}ourdain, {G}onzague and {N}go-{G}iang-{H}uong, {N}icole and {B}urchett, {S}. and {F}renkel, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {C}ongenital cytomegalovirus (c{CMV}) infection is common among infants born to {HIV}-infected women. {N}elfinavir ({NFV}), an antiretroviral drug that is safe during pregnancy, inhibits {CMV} replication in vitro at concentrations that standard doses achieve in plasma. {W}e hypothesized that infants born to women receiving {NFV} for prevention of mother-to-child transmission of {HIV} ({PMTCT}) would have a reduced prevalence of c{CMV} infection. {M}ethods: {T}he prevalence of c{CMV} infection was compared among {HIV}-uninfected infants whose {HIV}-infected mothers either received {NFV} for 4 weeks during pregnancy ({NFV}-exposed) or did not receive any {NFV} in pregnancy ({NFV}-unexposed). {CMV} {PCR} was performed on infant blood samples collected at <3 weeks from birth. {R}esults: {O}f the 1,255 women included, 314 received {NFV} for 4 weeks during pregnancy and 941 did not receive any {NFV} during pregnancy. {T}he overall prevalence of c{CMV} infection in the infants was 2.2%, which did not differ by maternal {NFV} use. {M}aternal {CD}4 {T} cell counts were inversely correlated with risk of c{CMV} infection, independent of the time {NFV} was initiated during gestation. {I}nfants with c{CMV} infection were born 0.7 weeks earlier ({P}=0.010) and weighed 170g less ({P}=0.009) than uninfected infants. {C}onclusion: {A}mong {HIV}-exposed uninfected infants, c{CMV} infection was associated with adverse perinatal outcomes. {NFV} use in pregnancy was not associated with protection against c{CMV}. {S}afe and effective strategies to prevent c{CMV} infection are needed. {J}. {M}ed. {V}irol. 88:1051-1058, 2016.},
  keywords = {congenital cytomegalovirus infection ; nelfinavir ; {HIV}-exposed uninfected ; infants ; {ETATS} {UNIS} ; {EUROPE} ; {BRESIL} ; {BAHAMAS}},
  booktitle = {},
  journal = {{J}ournal of {M}edical {V}irology},
  volume = {88},
  numero = {6},
  pages = {1051--1058},
  ISSN = {0146-6615},
  year = {2016},
  DOI = {10.1002/jmv.24420},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066767},
}