@article{fdi:010066751,
  title = {{M}ortality, morbidity, and developmental outcomes in infants born to women who received either mefloquine or sulfadoxine-pyrimethamine as intermittent preventive treatment of malaria in pregnancy : a cohort study},
  author = {{R}up{\'e}rez, {M}. and {G}onzalez, {R}. and {M}ombo-{N}goma, {G}. and {K}abanywanyi, {A}. {M}. and {S}evene, {E}. and {O}u{\'e}draogo, {S}. and {K}akolwa, {M}. {A}. and {V}ala, {A}. and {A}ccrombessi, {M}. and {B}riand, {V}al{\'e}rie and {A}ponte, {J}. {J}. and {Z}oleko, {R}. {M}. and {A}degnika, {A}. {A}. and {C}ot, {M}ichel and {K}remsner, {P}. {G}. and {M}assougbodji, {A}. and {A}bdulla, {S}. and {R}amharter, {M}. and {M}acete, {E}. and {M}enendez, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {L}ittle is known about the effects of intermittent preventive treatment of malaria in pregnancy ({IPT}p) on the health of sub-{S}aharan {A}frican infants. {W}e have evaluated the safety of {IPT}p with mefloquine ({MQ}) compared to sulfadoxine- pyrimethamine ({SP}) for important infant health and developmental outcomes. {M}ethods and {F}indings {I}n the context of a multicenter randomized controlled trial evaluating the safety and efficacy of {IPT}p with {MQ} compared to {SP} in pregnancy carried out in four sub-{S}aharan countries ({M}ozambique, {B}enin, {G}abon, and {T}anzania), 4,247 newborns, 2,815 born to women who received {MQ} and 1,432 born to women who received {SP} for {IPT}p, were followed up until 12 mo of age. {A}nthropometric parameters and psychomotor development were assessed at 1, 9, and 12 mo of age, and the incidence of malaria, anemia, hospital admissions, outpatient visits, and mortality were determined until 12 mo of age. {N}o significant differences were found in the proportion of infants with stunting, underweight, wasting, and severe acute malnutrition at 1, 9, and 12 mo of age between infants born to women who were on {IPT}p with {MQ} versus {SP}. {E}xcept for three items evaluated at 9 mo of age, no significant differences were observed in the psychomotor development milestones assessed. {I}ncidence of malaria, anemia, hospital admissions, outpatient visits, and mortality were similar between the two groups. {I}nformation on the outcomes at 12 mo of age was unavailable in 26% of the infants, 761 (27%) from the {MQ} group and 377 (26%) from the {SP} group. {R}easons for not completing the study were death (4% of total study population), study withdrawal (6%), migration (8%), and loss to follow-up (9%). {C}onclusions {N}o significant differences were found between {IPT}p with {MQ} and {SP} administered in pregnancy on infant mortality, morbidity, and nutritional outcomes. {T}he poorer performance on certain psychomotor development milestones at 9 mo of age in children born to women in the {MQ} group compared to those in the {SP} group may deserve further studies.},
  keywords = {{MOZAMBIQUE} ; {BENIN} ; {GABON} ; {TANZANIE} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{P}los {M}edicine},
  volume = {13},
  numero = {2},
  pages = {e1001964 [18 ]},
  ISSN = {1549-1676},
  year = {2016},
  DOI = {10.1371/journal.pmed.1001964},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066751},
}