@article{fdi:010066678,
  title = {{I}nsights into a new {C}itrobacter koseri strain revealed gene exchanges with the virulence-associated {Y}ersinia pestis ppcp1 plasmid},
  author = {{A}rmougom, {F}abrice and {B}itam, {I}. and {C}roce, {O}. and {M}erhej, {V}. and {B}arassi, {L}. and {N}guyen, {T}. {T}. and {L}a {S}cola, {B}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he history of infectious diseases raised the plague as one of the most devastating for human beings. {F}ar too often considered an ancient disease, the frequent resurgence of the plague has led to consider it as a reemerging disease in {M}adagascar, {A}lgeria, {L}ibya, and {C}ongo. {T}he genetic factors associated with the pathogenicity of {Y}ersinia pestis, the causative agent of the plague, involve the acquisition of the p{PCP}1 plasmid that promotes host invasion through the expression of the virulence factor {P}la. {T}he surveillance of plague foci after the 2003 outbreak in {A}lgeria resulted in a positive detection of the specific pla gene of {Y}. pestis in rodents. {H}owever, the phenotypic characterization of the isolate identified a {C}itrobacter koseri. {T}he comparative genomics of our sequenced {C}. koseri {URMITE} genome revealed a mosaic gene structure resulting from the lifestyle of our isolate and provided evidence for gene exchanges with different enteric bacteria. {T}he most striking was the acquisition of a continuous 2 kb genomic fragment containing the virulence factor {P}la of the {Y}. pestis p{PCP}1 plasmid; however, the subcutaneous injection of the {CKU} strain in mice did not produce any pathogenic effect. {O}ur findings demonstrate that fast molecular detection of plague using solely the pla gene is unsuitable and should rather require {Y}. pestis gene marker combinations. {W}e also suggest that the evolutionary force that might govern the expression of pathogenicity can occur through the acquisition of virulence genes but could also require the loss or the inactivation of resident genes such as antivirulence genes.},
  keywords = {genomics and evolution ; plague pathogenesis ; bioinformatics ; {C}itrobacter koseri ; virulence factors ; {ALGERIE}},
  booktitle = {},
  journal = {{F}rontiers in {M}icrobiology},
  volume = {7},
  numero = {},
  pages = {art. 340 [13 p.]},
  ISSN = {1664-302{X}},
  year = {2016},
  DOI = {10.3389/fmicb.2016.00340},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066678},
}