@article{fdi:010066662,
  title = {{D}ynamics of the human infectious reservoir for malaria determined by mosquito feeding assays and ultrasensitive malaria diagnosis in {B}urkina {F}aso},
  author = {{O}u{\'e}draogo, {A}. {L}. and {G}oncalves, {B}. {P}. and {G}n{\'e}m{\'e}, {A}. and {W}enger, {E}. {A}. and {G}uelbeogo, {M}. {W}. and {O}u{\'e}draogo, {A}. and {G}erardin, {J}. and {B}ever, {C}. {A}. and {L}yons, {H}. and {P}itroipa, {X}. and {V}erhave, {J}. {P}. and {E}ckhoff, {P}. {A}. and {D}rakeley, {C}. and {S}auerwein, {R}. and {L}uty, {A}drian and {K}ouyat{\'e}, {B}. and {B}ousema, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lasmodium falciparum gametocytes are essential for malaria transmission. {M}alaria control measures that aim at reducing transmission require an accurate characterization of the human infectious reservoir. {W}e longitudinally determined human infectiousness to mosquitoes and {P}. falciparum carriage by an ultrasensitive {RNA}-based diagnostics in 130 randomly selected inhabitants of an endemic area. {A}t least 1 mosquito was infected by 32.6% (100 of 307) of the blood samples; in total, 7.6% of mosquitoes (916 of 12 079) were infected. {T}he proportion of infectious individuals and infected mosquitoes were negatively associated with age and positively with asexual parasites ({P} < .001). {H}uman infectiousness was higher at the start of the wet season and subsequently declined at the peak of the wet season (adjusted odds ratio, 0.52; {P} = .06) and in the dry season (0.23; {P} < .001). {O}verall, microscopy-negative individuals were responsible for 28.7% of infectious individuals (25 of 87) and 17.0% of mosquito infections (145 of 855). {O}ur study reveals that the infectious reservoir peaks at the start of the wet season, with prominent roles for infections in children and submicroscopic infections. {T}hese findings have important consequences for strategies and the timing of interventions, which need to include submicroscopic infections and be implemented in the dry season.},
  keywords = {malaria ; falciparum ; gametocyte ; reservoir ; season ; dynamics ; {QT}-{NASBA} ; mosquito ; feeding ; {B}urkina {F}aso ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {213},
  numero = {1},
  pages = {90--99},
  ISSN = {0022-1899},
  year = {2016},
  DOI = {10.1093/infdis/jiv370},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066662},
}