@article{fdi:010066277,
  title = {{A} seroepidemiological study of serogroup {A} meningococcal infection in the african meningitis belt},
  author = {{M}anigart, {O}. and {T}rotter, {C}. and {F}indlow, {H}. and {A}ssefa, {A}. and {M}ihret, {W}. and {D}emisse, {T}. {M}. and {Y}eshitela, {B}. and {O}sei, {I}. and {H}odgson, {A}. and {Q}uaye, {S}. {L}. and {S}ow, {S}. and {C}oulibaly, {M}. and {D}iallo, {K}. and {T}raore, {A}. and {C}ollard, {J}. {M}. and {B}oukary, {R}. {M}. and {D}jermakoye, {O}. and {M}ahamane, {A}. {E}. and {J}usot, {J}. {F}. and {S}okhna, {C}heikh and {A}lavo, {S}. and {D}oucour{\'e}, {S}ouleymane and {B}a, {E}l {H}adj and {D}ieng, {M}. and {D}iallo, {A}ldiouma and {D}augla, {D}. {M}. and {O}motara, {B}. and {C}handramohan, {D}. and {H}assan-{K}ing, {M}. and {N}ascimento, {M}. and {W}oukeu, {A}. and {B}orrow, {R}. and {S}tuart, {J}. {M}. and {G}reenwood, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he pattern of epidemic meningococcal disease in the {A}frican meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. {A} standardised enzyme-linked immunosorbent assay ({ELISA}) for measuring meningococcal serogroup {A} {I}g{G} antibodies was established at five centres within the meningitis belt. {A}ntibody concentrations were then measured in 3930 individuals stratified by age and residence from six countries. {S}eroprevalence by age was used in a catalytic model to determine the force of infection. {M}eningococcal serogroup {A} {I}g{G} antibody concentrations were high in each country but showed heterogeneity across the meningitis belt. {T}he geometric mean concentration ({GMC}) was highest in {G}hana (9.09 mu g/m{L} [95% {CI} 8.29, 9.97]) and lowest in {E}thiopia (1.43 mu g/m{L} [95% {CI} 1.31, 1.57]) on the margins of the belt. {T}he force of infection was lowest in {E}thiopia (lambda = 0.028). {V}ariables associated with a concentration above the putative protective level of 2 mu g/m{L} were age, urban residence and a history of recent vaccination with a meningococcal vaccine. {P}rior to vaccination with the serogroup {A} meningococcal conjugate vaccine, meningococcal serogroup {A} {I}g{G} antibody concentrations were high across the {A}frican meningitis belt and yet the region remained susceptible to epidemics.},
  keywords = {{SENEGAL} ; {NIGER} ; {MALI} ; {GHANA} ; {ETHIOPIE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {11},
  numero = {2},
  pages = {e0147928 [12 p.]},
  ISSN = {1932-6203},
  year = {2016},
  DOI = {10.1371/journal.pone.0147928},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066277},
}