@article{fdi:010066227,
  title = {{D}evelopment of a murine infection model with {L}eishmania killicki, responsible for cutaneous {L}eishmaniosis in {A}lgeria : application in pharmacology},
  author = {{E}ddaikra, {N}. and {D}jenad, {I}. {K}. and {B}enbetka, {S}. and {B}enikhlef, {R}. and {A}it-{O}udhia, {K}. and {M}oulti-{M}ati, {F}. and {O}ury, {B}runo and {S}ereno, {D}enis and {H}arrat, {Z}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n {A}lgeria, {L}eishmania infantum, {L}eishmania major, and {L}eishmania killicki ({L}eishmania tropica) are responsible for cutaneous leishmaniosis. {W}e established a murine model of {L}. killicki infection to investigate its infective capacity, some immunophysiopathological aspects, and its suitability for pharmacological purposes. {F}ollowing the injection of {L}. major or {L}. killicki metacyclic promastigotes in the ear dermis of {BALB}/c mice, the course of infection was followed. {T}he infection with {L}. killicki caused slower lesion formation than with {L}. major. {T}he presence of {L}. killicki or {L}. major {DNA} and parasites was detected in the ear dermis and in lymph nodes, spleen, and liver. {L}esions induced by {L}. killicki were nonulcerative in their aspect, whereas those caused by {L}. major were highly ulcerative and necrotic, which matches well with the lesion phenotype reported in humans for {L}. killicki and {L}. major, respectively. {T}he treatment of {L}. killicki lesions by injection of {G}lucantime ({R}) significantly reduced the lesion thickness and parasite burden. {E}ar dermal injection of {BALB}/c mice constitutes a model to study lesions physiopathology caused by {L}. killicki and presents interest for in vivo screening of new compounds against this pathogen, emerging in {A}lgeria.},
  keywords = {{ALGERIE}},
  booktitle = {},
  journal = {{B}iomed {R}esearch {I}nternational},
  numero = {},
  pages = {art. 7985104},
  ISSN = {2314-6133},
  year = {2016},
  DOI = {10.1155/2016/7985104},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066227},
}