@article{fdi:010066206,
  title = {{T}iming of malaria in pregnancy and impact on infant growth and morbidity : a cohort study in {U}ganda},
  author = {{B}eaudrap, {P}ierre de and {T}uryakira, {E}. and {N}abasumba, {C}. and {T}umwebaze, {B}. and {P}iola, {P}. and {B}oum, {Y}. and {M}c{G}ready, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}alaria in pregnancy ({M}i{P}) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-{S}aharan {A}frica. {U}nderstanding of the impact of {M}i{P} on infant growth and infant risk of malaria or morbidity is poorly characterized. {T}he objective of this study was to describe the impact of {MIP} on subsequent infant growth, malaria and morbidity. {M}ethods: {B}etween 2006 and 2009, 82 % (832/1018) of pregnant women with live-born singletons and ultrasound determined gestational age were enrolled in a prospective cohort with active weekly screening and treatment for malaria. {I}nfants were followed monthly for growth and morbidity and received active monthly screening and treatment for malaria during their first year of life. {M}ultivariate analyses were performed to analyse the association between malaria exposure during pregnancy and infants' growth, malaria infections, diarrhoea episodes and acute respiratory infections. {R}esults: {M}edian time of infant follow-up was 12 months and infants born to a mother who had {M}i{P} were at increased risk of impaired height and weight gain (-2.71 cm, 95 % {CI} -4.17 to -1.25 and -0.42 kg, 95 % {CI} -0.76 to -0.08 at 12 months for > 1 {M}i{P} compared to no {M}i{P}) and of malaria infection (relative risk 10.42, 95 % {CI} 2.64-41.10 for infants born to mothers with placental malaria). {T}he risks of infant growth restriction and infant malaria infection were maximal when maternal malaria occurred in the 12 weeks prior to delivery. {R}ecurrent {M}i{P} was also associated with acute respiratory infection ({RR} 1.96, 95 % {CI} 1.25-3.06) and diarrhoea during infancy ({RR} 1.93, 95 % {CI} 1.02-3.66). {C}onclusion: {T}his study shows that despite frequent active screening and prompt treatment of {M}i{P}, impaired growth and an increased risk of malaria and non-malaria infections can be observed in the infants. {E}ffective preventive measures in pregnancy remain a research priority.},
  keywords = {{M}alaria in pregnancy ; {I}nfant growth ; {S}ub-{S}aharan {A}frica ; {C}ohort ; {OUGANDA} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {15},
  numero = {},
  pages = {art. 92 [9 p.]},
  ISSN = {1475-2875},
  year = {2016},
  DOI = {10.1186/s12936-016-1135-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066206},
}