d'Almeida T. C., Sadissou I., Cottrell Gilles, Tahar Rachida, Moreau P., Favier B., Moutairou K., Donadi E. A., Massougbodji A., Rouass-Freiss N., Courtin David, Garcia André. (2016). Evolution of the levels of human leukocyte antigen G (HLA-G) in Beninese infant during the first year of life in a malaria endemic area : using latent class analysis. Malaria Journal, 15, p. art. 78 [10 p.]. ISSN 1475-2875.
Titre du document
Evolution of the levels of human leukocyte antigen G (HLA-G) in Beninese infant during the first year of life in a malaria endemic area : using latent class analysis
Année de publication
2016
Auteurs
d'Almeida T. C., Sadissou I., Cottrell Gilles, Tahar Rachida, Moreau P., Favier B., Moutairou K., Donadi E. A., Massougbodji A., Rouass-Freiss N., Courtin David, Garcia André
Source
Malaria Journal, 2016,
15, p. art. 78 [10 p.] ISSN 1475-2875
Background: HLA-G, a non-classical HLA class I antigen, is of crucial interest during pregnancy by inhibiting maternal immune response. Its role during infections is discussed, and it has been described that high levels of soluble HLA-G during childhood increase the risk of malaria. To explore more precisely interactions between soluble HLA-G and malaria, latent class analysis was used to test whether distinct sub-populations of children, each with distinctive soluble HLA-G evolutions may suggest the existence of groups presenting variable malaria susceptibility. Method: A study was conducted in Benin from 2010 to 2013 and 165 children were followed from birth to 12 months. Evolution of soluble HLA-G was studied by the latent class method. Results: Three groups of children were identified: one with consistently low levels of soluble HLA-G during follow-up, a second with very high levels and a last intermediate group. In all groups, low birth weight, high number of malaria infections and high exposure to malaria transmission were associated with high level of soluble HLA-G. Placental malaria was not. Presence of soluble HLA-G in cord blood increased the probability of belonging to the highest trajectory. Conclusion: These results, together with previous ones, confirm the important role of HLA-G in the individual susceptibility to malaria. Assaying soluble HLA-G at birth could be a good indicator of newborns more fragile and at risk of infections during childhood.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010066187]
Identifiant IRD
fdi:010066187
