@article{fdi:010066176,
  title = {{F}easibility and efficacy of early lung cancer diagnosis with chest computed tomography in {HIV}-infected smokers},
  author = {{M}akinson, {A}. and {E}ymard-{D}uvernay, {S}abrina and {R}affi, {F}. and {A}bgrall, {S}. and {B}ommart, {S}. and {Z}ucman, {D}. and {V}alour, {F}. and {C}heret, {A}. and {P}oizot-{M}artin, {I}. and {D}uvivier, {C}. and {M}auboussin, {J}. {M}. and {B}onnet, {F}. and {T}attevin, {P}. and {R}eynes, {J}. and {L}e {M}oing, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective:{L}ung cancer screening with chest computed tomography ({CT}) is beneficial in smokers aged 55 to 74 years. {W}e studied the risks, benefits and feasibility of early lung cancer diagnosis with {CT} in {HIV}-infected smokers.{D}esign and setting:{F}rench, multicentre, single round chest {CT} study in {F}rance, realized between {F}ebruary 2011 and {J}une 2012.{P}articipants:{P}atients were {HIV}-infected smokers at least 40 years, at least 20 pack-years, with a {CD}4(+) {T}-lymphocyte nadir count below 350 cells/l.{I}ntervention:{S}ingle chest {CT} with a proposed standardized workup algorithm of positive images.{M}ain outcome measure:{T}he outcome was the number of histologically proven lung cancers diagnosed by {CT} with a 2-year follow-up.{R}esults:{M}edian age of the 442 included patients was 49.8 years, 81.6% were under 55 years, 84% were men, median smoking was 30 pack-years, median nadir and last {CD}4(+) cell counts were 168 and 574 cells/l, respectively, and 90% of patients had a plasma {HIV} {RNA} below 50copies/ml. {A} positive image at baseline was reported in 94 (21%) patients, and 15 (3.4%) patients had 18 invasive procedures with no serious adverse events. {L}ung cancer was diagnosed in 10 patients (six at early stages), of which nine (2.0%, 95% confidence interval: 0.9-3.8) were {CT} detected, and eight in patients below 55 years.{C}onclusion:{E}arly lung cancer diagnosis with {CT} in {HIV}-infected smokers was feasible, safe, and yielded a significant number of cancers. {L}ung cancer screening of {HIV}-infected smokers with an important history of immunodeficiency revealed a substantial number of cancers at younger ages than the targeted range in the general population.},
  keywords = {computed tomography ; {HIV} ; lung cancer ; screen ; smoking ; {FRANCE}},
  booktitle = {},
  journal = {{A}ids},
  volume = {30},
  numero = {4},
  pages = {573--581},
  ISSN = {0269-9370},
  year = {2016},
  DOI = {10.1097/qad.0000000000000943},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066176},
}