Ilboudo H., Camara O., Ravel Sophie, Bucheton Bruno, Lejon Veerle, Camara M., Kabore J., Jamonneau Vincent, Deborggraeve S. (2015). Trypanosoma brucei gambiense spliced leader RNA is a more specific marker for cure of human African trypanosomiasis than T. b. gambiense DNA. Journal of Infectious Diseases, 212 (12), p. 1996-1998. ISSN 0022-1899.
Titre du document
Trypanosoma brucei gambiense spliced leader RNA is a more specific marker for cure of human African trypanosomiasis than T. b. gambiense DNA
Ilboudo H., Camara O., Ravel Sophie, Bucheton Bruno, Lejon Veerle, Camara M., Kabore J., Jamonneau Vincent, Deborggraeve S.
Source
Journal of Infectious Diseases, 2015,
212 (12), p. 1996-1998 ISSN 0022-1899
To assess the efficacy of treatment for human African trypanosomiasis, accurate tests that can discriminate relapse from cure are needed. We report the first data that the spliced leader (SL) RNA is a more specific marker for cure of human African trypanosomiasis than parasite DNA. In blood samples obtained from 61 patients in whom human African trypanosomiasis was cured, SL RNA detection had specificities of 98.4%-100%, while DNA detection had a specificity of only 77%. Data from our proof-of-concept study show that SL RNA detection has high potential as a test of cure.
