@article{fdi:010066137,
  title = {{C}omparison of {L}eishmania killicki (syn. {L}-tropica) and {L}eishmania tropica population structure in {M}aghreb by microsatellite typing},
  author = {{C}haara, {D}. and {B}anuls, {A}nne-{L}aure and {H}aouas, {N}. and {T}alignani, {L}. and {L}ami, {P}. and {M}ezhoud, {H}. and {H}arrat, {Z}. and {D}edet, {J}. {P}. and {B}abba, {H}. and {P}ratlong, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}eishmania ({L}.) killicki (syn. {L}. tropica), which causes cutaneous leishmaniasis in {M}aghreb, was recently described in this region and identified as a subpopulation of {L}. tropica. {T}he present genetic analysis was conducted to explore the spatio-temporal distribution of {L}. killicki (syn. {L}. tropica) and its transmission dynamics. {T}o better understand the evolution of this parasite, its population structure was then compared with that of {L}. tropica populations from {M}orocco. {I}n total 198 samples including 85 {L}. killicki (syn. {L}. tropica) (from {T}unisia, {A}lgeria and {L}ibya) and 113 {L}. tropica specimens (all from {M}orocco) were tested. {T}heses samples were composed of 168 {L}eishmania strains isolated from human skin lesions, 27 {DNA} samples from human skin lesion biopsies, two {DNA} samples from {C}tenodactylus gundi bone marrow and one {DNA} sample from a {P}hlebotomus sergenti female. {T}he sample was analyzed by using {M}ulti{L}ocus {E}nzyme {E}lectrophoresis ({MLEE}) and {M}ulti{L}ocus {M}icrosatellite {T}yping ({MLMT}) approaches. {A}nalysis of the {MLMT} data support the hypothesis that {L}. killicki (syn. {L}. tropica) belongs to the {L}. tropica complex, despite its strong genetic differentiation, and that it emerged from this taxon by a founder effect. {M}oreover, it revealed a strong structuring in {L}. killicki (syn. {L}. tropica) between {T}unisia and {A}lgeria and within the different {T}unisian regions, suggesting low dispersion of {L}. killicki (syn. {L}. tropica) in space and time. {C}omparison of the {L}. tropica (exclusively from {M}orocco) and {L}. killicki (syn. {L}. tropica) population structures revealed distinct genetic organizations, reflecting different epidemiological cycles.},
  keywords = {{MAROC} ; {ALGERIE} ; {TUNISIE} ; {LIBYE} ; {MAGHREB}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {9},
  numero = {12},
  pages = {art. e0004204 [13 ]},
  ISSN = {1935-2735},
  year = {2015},
  DOI = {10.1371/journal.pntd.0004204},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066137},
}