%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ogouyemi-Hounto, A.
%A Azandossessi, C.
%A Lawani, S.
%A Damien, G.
%A de Tove, Y. S. S.
%A Remoué, Franck
%A Gazard, D. K.
%T Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Benin
%D 2016
%L fdi:010066134
%G ENG
%J Malaria Journal
%@ 1475-2875
%K Efficacy ; Artemether-lumefantrine ; Falciparum malaria ; Benin
%K BENIN
%M ISI:000368594500005
%P art. 37 [8 ]
%R 10.1186/s12936-016-1091-2
%U https://www.documentation.ird.fr/hor/fdi:010066134
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers16-02/010066134.pdf
%V 15
%W Horizon (IRD)
%X Background: Artemether/lumefantrine (Coartem (R)) has been used as a treatment for uncomplicated Plasmodium falciparum infection since 2004 in Benin. This open-label, non-randomized study evaluated efficacy of artemether-lumefantrine (AL) in treatment of uncomplicated falciparum malaria in children aged 6-59 months in two malaria transmission sites in northwest Benin. Methods: A 42-day therapeutic efficacy study was conducted between August and November 2014, in accordance with 2009 WHO guidelines. One-hundred and twenty-three children, aged 6 months to 5 years, with uncomplicated falciparum malaria were recruited into the study. The primary endpoint was parasitological cure on day 28 and day 42 while the secondary endpoints included: parasite and fever clearance, improvement in haemoglobin levels. Outcomes were classified as early treatment failure (ETF), late clinical failure, late parasitological failure, and adequate clinical and parasitological response (ACPR). Results: Before PCR correction, ACPR rates were 87 % (95 % CI 76.0-94.7) and 75.6 %, respectively (95 % CI 67.0-82.9) on day 28 and day 42. In each study site, ACPR rates were 78.3 % in Djougou and 73 % in Cobly on day 42. There was no ETF and after PCR correction ACPR was 100 % in study population. All treatment failures were shown to be due to new infections. Fever was significantly cleared in 24 h and approximately 90 % of parasites where cleared on day 1 and almost all parasites were cleared on day 2. Haemoglobin concentration showed a slight increase with parasitic clearance. Conclusion: AL remains an efficacious drug for the treatment of uncomplicated falciparum malaria in Benin, although higher rates of re-infection remain a concern. Surveillance needs to be continued to detect future changes in parasite sensitivity to artemisinin-based combination therapy.
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