@article{fdi:010066134,
  title = {{T}herapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest {B}enin},
  author = {{O}gouyemi-{H}ounto, {A}. and {A}zandossessi, {C}. and {L}awani, {S}. and {D}amien, {G}. and de {T}ove, {Y}. {S}. {S}. and {R}emou{\'e}, {F}ranck and {G}azard, {D}. {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}rtemether/lumefantrine ({C}oartem ({R})) has been used as a treatment for uncomplicated {P}lasmodium falciparum infection since 2004 in {B}enin. {T}his open-label, non-randomized study evaluated efficacy of artemether-lumefantrine ({AL}) in treatment of uncomplicated falciparum malaria in children aged 6-59 months in two malaria transmission sites in northwest {B}enin. {M}ethods: {A} 42-day therapeutic efficacy study was conducted between {A}ugust and {N}ovember 2014, in accordance with 2009 {WHO} guidelines. {O}ne-hundred and twenty-three children, aged 6 months to 5 years, with uncomplicated falciparum malaria were recruited into the study. {T}he primary endpoint was parasitological cure on day 28 and day 42 while the secondary endpoints included: parasite and fever clearance, improvement in haemoglobin levels. {O}utcomes were classified as early treatment failure ({ETF}), late clinical failure, late parasitological failure, and adequate clinical and parasitological response ({ACPR}). {R}esults: {B}efore {PCR} correction, {ACPR} rates were 87 % (95 % {CI} 76.0-94.7) and 75.6 %, respectively (95 % {CI} 67.0-82.9) on day 28 and day 42. {I}n each study site, {ACPR} rates were 78.3 % in {D}jougou and 73 % in {C}obly on day 42. {T}here was no {ETF} and after {PCR} correction {ACPR} was 100 % in study population. {A}ll treatment failures were shown to be due to new infections. {F}ever was significantly cleared in 24 h and approximately 90 % of parasites where cleared on day 1 and almost all parasites were cleared on day 2. {H}aemoglobin concentration showed a slight increase with parasitic clearance. {C}onclusion: {AL} remains an efficacious drug for the treatment of uncomplicated falciparum malaria in {B}enin, although higher rates of re-infection remain a concern. {S}urveillance needs to be continued to detect future changes in parasite sensitivity to artemisinin-based combination therapy.},
  keywords = {{E}fficacy ; {A}rtemether-lumefantrine ; {F}alciparum malaria ; {B}enin ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {15},
  numero = {},
  pages = {art. 37 [8 p.]},
  ISSN = {1475-2875},
  year = {2016},
  DOI = {10.1186/s12936-016-1091-2},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066134},
}