@article{fdi:010066102,
  title = {{T}he guardians of inherited oncogenic vulnerabilities},
  author = {{A}rnal, {A}. and {T}issot, {T}. and {U}jvari, {B}. and {N}unney, {L}. and {S}olary, {E}. and {L}aplane, {L}. and {B}onhomme, {F}. and {V}ittecoq, {M}. and {T}asiemski, {A}. and {R}enaud, {F}. and {P}ujol, {P}. and {R}oche, {B}enjamin and {T}homas, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}imilar to seemingly maladaptive genes in general, the persistence of inherited cancer-causing mutant alleles in populations remains a challenging question for evolutionary biologists. {I}n addition to traditional explanations such as senescence or antagonistic pleiotropy, here we put forward a new hypothesis to explain the retention of oncogenic mutations. {W}e propose that although natural defenses evolve to prevent neoplasm formation and progression thus increasing organismal fitness, they also conceal the effects of cancer-causing mutant alleles on fitness and concomitantly protect inherited ones from purging by purifying selection. {W}e also argue for the importance of the ecological contexts experienced by individuals and/or species. {T}hese contexts determine the locally predominant fitness-reducing risks, and hence can aid the prediction of how natural selection will influence cancer outcomes.},
  keywords = {{C}ancer ; natural defenses ; purifying selection ; somatic mutations},
  booktitle = {},
  journal = {{E}volution},
  volume = {70},
  numero = {1},
  pages = {1--6},
  ISSN = {0014-3820},
  year = {2016},
  DOI = {10.1111/evo.12809},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066102},
}