@article{fdi:010066059,
  title = {{P}lacental malaria : decreased transfer of maternal antibodies directed to {P}lasmodium falciparum and impact on the incidence of febrile infections in infants},
  author = {{D}echavanne, {C}. and {C}ottrell, {G}illes and {G}arcia, {A}ndr{\'e} and {M}igot {N}abias, {F}lorence},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he efficacy of mother-to-child placental transfer of antibodies specific to malaria blood stage antigens was investigated in the context of placental malaria infection, taking into account {I}g{G} specificity and maternal hypergammaglobulinemia. {T}he impact of the resulting maternal antibody transfer on infections in infants up to the age of 6 months was also explored. {T}his study showed that i) placental malaria was associated with a reduced placental transfer of total and specific {I}g{G}, ii) antibody placental transfer varied according to {I}g{G} specificity and iii) cord blood malaria {I}g{G} levels were similar in infants born to mothers with or without placental malaria. {T}he number of malaria infections was negatively associated with maternal age, whereas it was not associated with the transfer of any malaria-specific {I}g{G} from the mother to the fetus. {T}hese results suggest that i) malaria-specific {I}g{G} may serve as a marker of maternal exposure but not as a useful marker of infant protection from malaria and ii) increasing maternal age contributes to diminishing febrile infections diagnosed in infants, perhaps by means of the transmission of an effective antibody response.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {10},
  numero = {12},
  pages = {e0145464 [11 p.]},
  ISSN = {1932-6203},
  year = {2015},
  DOI = {10.1371/journal.pone.0145464},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066059},
}