@article{fdi:010066026,
  title = {{S}pecific effects of dietary methylmercury and inorganic mercury in zebrafish ({D}anio rerio) determined by genetic, histological, and metallothionein responses},
  author = {{G}entes, {S}. and {M}aury-{B}rachet, {R}. and {F}eng, {C}. {Y}. and {P}edrero, {Z}. and {T}essier, {E}. and {L}egeay, {A}. and {M}esmer-{D}udons, {N}. and {B}audrimont, {M}. and {M}aurice, {L}aurence and {A}mouroux, {D}. and {G}onzalez, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} multidisciplinary approach is proposed here to compare toxicity mechanisms of methylmercury ({M}e{H}g) and inorganic mercury (i{H}g) in muscle, liver, and brain from zebrafish ({D}anio rerio). {A}nimals were dietary exposed to (1) 50 ng {H}g g(-1), 80% as {M}e{H}g; (2) diet enriched in {M}e{H}g 10000 ng {H}g g(-1) 95% as {M}e{H}g; (3) diet enriched in i{H}g 10000 ng {H}g g-1, 99% as i{H}g, for two months. {H}g species specific bioaccumulation pathways were highlighted, with a preferential bioaccumulation of {M}e{H}g in brain and i{H}g in liver. {I}n the same way, differences in genetic pattern were observed for both {H}g species, (an early genetic response (7 days) for both species in the three organs and a late genetic response (62 days) for i{H}g) and revealed a dissimilar metabolization of both {H}g species. {A}mong the 18 studied genes involved in key metabolic pathways of the cell, major genetic responses were observed in muscle. {E}lectron microscopy revealed damage mainly because of {M}e{H}g in muscle and also in liver tissue. {I}n brain, high {M}e{H}g and i{H}g concentrations induced metallothionein production. {F}inally, the importance of the fish origin in ecotoxicological studies, here the seventh descent of a zebrafish line, is discussed.},
  keywords = {},
  booktitle = {},
  journal = {{E}nvironmental {S}cience and {T}echnology},
  volume = {49},
  numero = {24},
  pages = {14560--14569},
  ISSN = {0013-936{X}},
  year = {2015},
  DOI = {10.1021/acs.est.5b03586},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066026},
}