@article{fdi:010066020,
  title = {{A}dministration of ivermectin to peridomestic cattle : a promising approach to target the residual transmission of human malaria},
  author = {{P}ooda, {H}. {S}. and {R}ayaisse, {J}. {B}. and {H}ien, {D}. {F}. {D}. and {L}ef{\`e}vre, {T}. and {Y}erbanga, {S}. {R}. and {B}engaly, {Z}. and {D}abire, {R}. {K}. and {B}elem, {A}. {M}. {G}. and {S}idibe, {I}. and {S}olano, {P}hilippe and {M}ouline, {K}arine},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he success of current control tools in combatting malaria vectors is well established. {H}owever, sustained residual transmission of {P}lasmodium parasites persists. {M}ass drug administration ({MDA}) to humans of the endectocide ivermectin for vector control is receiving increasing attention. {H}owever, vectors feeding upon animals escape this promising approach. {Z}oophagy of mosquitoes sustains both the vector population and endemic population of vector-borne pathogens. {T}herefore, only a strategy that will combine ivermectin {MDA}s targeted at humans and their peridomestic animals could be successful at controlling residual malaria transmission. {M}ethods: {B}urkinabe cattle have been treated with injectable therapeutic dose of ivermectin (0.2 mg/kg of body weight) to render blood meals toxic to field representative populations of {A}nopheles coluzzii carrying the kdr mutation. {D}irect skin-feeding assays were performed from 2 to 28 days after injection ({DAI}) and mosquitoes were followed for their survival, ability to become gravid and fecundity. {M}embrane feeding assays were further performed to test if an ivermectin blood meal taken at 28 {DAI} impacts gametocyte establishment and development in females fed with infectious blood. {R}esults: {T}he mosquitocidal effect of ivermectin is complete for 2 weeks after injection, whether 12 days cumulative mortalities were of 75 and 45 % the third and fourth weeks, respectively. {T}he third week, a second ivermectin blood meal at sub-lethal concentrations further increased mortality to 100 %. {S}ub-lethal concentrations of ivermectin also significantly decreased egg production by surviving females, increasing further the detrimental effect of the drug on vector densities. {A}lthough females fitness was impaired by sub-lethal ivermectin blood meals, these did not diminish nor increase their susceptibility to infection. {C}onclusion: {T}his study demonstrates the potential of integrated {MDA} of ivermectin to both human and peridomestic cattle to target vector reservoirs of residual malaria transmission. {S}uch integration lies in '{O}ne-{H}ealth' efforts being implemented around the globe, and would be especially relevant in rural communities in {A}frica where humans are also at risk of common zoonotic diseases.},
  keywords = {{I}vermectin ; {C}attle ; {O}ne-{H}ealth ; {M}alaria ; {W}est {A}frica ; {A}nopheles coluzzii ; {S}urvival ; {F}ecundity ; {I}nfectivity ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {14},
  numero = {},
  pages = {art. 496 [12 ]},
  ISSN = {1475-2875},
  year = {2015},
  DOI = {10.1186/s12936-015-1001-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066020},
}