@article{fdi:010065662,
  title = {{E}nvironmental transmission of {M}ycobacterium ulcerans drives dynamics of {B}uruli ulcer in endemic regions of {C}ameroon},
  author = {{G}architorena, {A}ndres and {N}gonghala, {C}. {N}. and {T}exier, {G}. and {L}andier, {J}. and {E}yangoh, {S}. and {B}onds, {M}. {H}. and {G}u{\'e}gan, {J}ean-{F}ran{\c{c}}ois and {R}oche, {B}enjamin},
  editor = {},
  language = {{ENG}},
  abstract = {{B}uruli {U}lcer is a devastating skin disease caused by the pathogen {M}ycobacterium ulcerans. {E}mergence and distribution of {B}uruli ulcer cases is clearly linked to aquatic ecosystems, but the specific route of transmission of {M}. ulcerans to humans remains unclear. {R}elying on the most detailed field data in space and time on {M}. ulcerans and {B}uruli ulcer available today, we assess the relative contribution of two potential transmission routes -environmental and water bug transmission-to the dynamics of {B}uruli ulcer in two endemic regions of {C}ameroon. {T}he temporal dynamics of {B}uruli ulcer incidence are explained by estimating rates of different routes of transmission in mathematical models. {I}ndependently, we also estimate statistical models of the different transmission pathways on the spatial distribution of {B}uruli ulcer. {T}he results of these two independent approaches are corroborative and suggest that environmental transmission pathways explain the temporal and spatial patterns of {B}uruli ulcer in our endemic areas better than the water bug transmission.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {5},
  numero = {},
  pages = {art. 18055 [9 p.]},
  ISSN = {2045-2322},
  year = {2015},
  DOI = {10.1038/srep18055},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065662},
}