Publications des scientifiques de l'IRD

Peyriere H., Cournil Amandine, Casanova M. L., Badiou S., Cristol J. P., Reynes J. (2015). Long-term follow-up of proteinuria and estimated glomerular filtration rate in HIV-infected patients with tubular proteinuria. Plos One, 10 (11), e0142491 [8 p.]. ISSN 1932-6203.

Titre du document
Long-term follow-up of proteinuria and estimated glomerular filtration rate in HIV-infected patients with tubular proteinuria
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000365070700044
Auteurs
Peyriere H., Cournil Amandine, Casanova M. L., Badiou S., Cristol J. P., Reynes J.
Source
Plos One, 2015, 10 (11), e0142491 [8 p.] ISSN 1932-6203
Objective The objective of this prospective observational study was to describe the evolution of tubular proteinuria detected in HIV-infected patients, and to evaluate the impact of tenofovir disoproxil fumarate (TDF) discontinuation. Methods Proteinuria and estimated glomerular filtration rate (eGFR) were followed during a median duration of 32 months, in 81 HIV-infected patients with tubular proteinuria and eGFR >= 60 ml/min/1.73 m(2) (determined using the Chronic Kidney Disease Epidemiology (CKD-EPI) Collaboration equation). Tubular proteinuria was defined by urine protein to creatinine ratio (uPCR) >= 200 mg/g and albumin to protein ratio (uAPR) <0.4. Results Twenty per cent of patients had persistence of tubular proteinuria: TDF continuation was the main factor associated with this persistence [OR 9.0; 95% CI: 1.9-41.4; p = 0.01]. Among the 23 patients who discontinued TDF, uPCR returned below the threshold of 200 mg/g in 11 patients. Overall, eGFR decreased with a mean rate of decline of 3.8 ml/min/1.73m(2)/year. The decline in eGFR was lesser after discontinuation of TDF (5.8 ml/min/1.73m(2)/year during TDF exposure versus 3 ml/min/1.73m2/year after TDF discontinuation; p = 0.01). Conclusions The continuation of TDF was the main factor associated with the persistence of proteinuria. Moreover, proteinuria was normalized in only half of the patients who discontinued TDF. The clinical significance of TDF-related low level of proteinuria as a factor associated with renal disease progression and bone loss remains poorly understood.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010065660]
Identifiant IRD
fdi:010065660
Contact