@article{fdi:010065533,
  title = {{T}he epigenomic landscape of {A}frican rainforest hunter-gatherers and farmers},
  author = {{F}agny, {M}. and {P}atin, {E}. and {M}ac{I}saac, {J}. {L}. and {R}otival, {M}. and {F}lutre, {T}. and {J}ones, {M}. {J}. and {S}iddle, {K}. {J}. and {Q}uach, {H}. and {H}armant, {C}. and {M}c{E}wen, {L}. {M}. and {F}roment, {A}lain and {H}eyer, {E}. and {G}essain, {A}. and {B}etsem, {E}. and {M}ouguiama-{D}aouda, {P}. and {H}ombert, {J}. {M}. and {P}erry, {G}. {H}. and {B}arreiro, {L}. {B}. and {K}obor, {M}. {S}. and {Q}uintana-{M}urci, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he genetic history of {A}frican populations is increasingly well documented, yet their patterns of epigenomic variation remain uncharacterized. {M}oreover, the relative impacts of {DNA} sequence variation and temporal changes in lifestyle and habitat on the human epigenome remain unknown. {H}ere we generate genome-wide genotype and {DNA} methylation profiles for 362 rainforest hunter-gatherers and sedentary farmers. {W}e find that the current habitat and historical lifestyle of a population have similarly critical impacts on the methylome, but the biological functions affected strongly differ. {S}pecifically, methylation variation associated with recent changes in habitat mostly concerns immune and cellular functions, whereas that associated with historical lifestyle affects developmental processes. {F}urthermore, methylation variation-particularly that correlated with historical lifestyle-shows strong associations with nearby genetic variants that, moreover, are enriched in signals of natural selection. {O}ur work provides new insight into the genetic and environmental factors affecting the epigenomic landscape of human populations over time.},
  keywords = {{AFRIQUE}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {6},
  numero = {},
  pages = {art. 10047 [11 p.]},
  ISSN = {2041-1723},
  year = {2015},
  DOI = {10.1038/ncomms10047},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065533},
}