@article{fdi:010065519,
  title = {{V}irological outcome among {HIV}-1 infected patients on first-line antiretroviral treatment in semi-rural {HIV} clinics in {T}ogo},
  author = {{K}onou, {A}. {A}. and {S}alou, {M}. and {V}idal, {N}icole and {K}odah, {P}. and {K}ombate, {D}. and {K}panla, {P}. and {N}abroulaba, {T}. and {N}yametso, {D}. and {S}ingo-{T}okofai, {A}. and {P}itche, {P}. and {D}elaporte, {E}ric and {P}rince-{D}avid, {M}. and {P}eeters, {M}artine and {D}agnra, {A}. {Y}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}ccess to antiretroviral treatment ({ART}) in resource-limited countries has increased significantly but scaling-up {ART} into semi-rural and rural areas is more recent. {I}nformation on treatment outcome in such areas is still very limited notably due to additional difficulties to manage {ART} in these areas. {R}esults: 387 {HIV}-1 infected adults (>= 18 years) were consecutively enrolled when attending healthcare services for their routine medical visit at 12 or 24 months on first-line {ART} in five {HIV} care centers (four semi-rural and one rural). {A}mong them, 102 patients were on first-line {ART} for 12 +/- 2 months ({M}12) and 285 for 24 +/- 2 months ({M}24). {V}irological failure was observed in 70 (18.1 %) patients ranging from 13.9 to 31.6 % at {M}12 and from 8.1 to 22.4 % at {M}24 across the different sites. {F}or 67/70 patients, sequencing was successful and drug resistance mutations were observed in 65 (97 %). {T}he global prevalence of drug resistance in the study population was thus at least 16.8 % (65/387). {M}oreover, 32 (8.3 %) and 27 (6.9 %) patients were either on a completely ineffective {ART} regime or with only a single drug active. {S}everal patients accumulated high numbers of mutations and developed also cross-resistance to abacavir, didanosine or the new {NNRTI} drugs like etravirine and rilpivirine. {C}onclusion: {T}he observations on {ART} treatment outcome from {ART} clinics in semi-rural areas are close to previous observations in {L}om the capital city suggesting that national {ART}-programme management plays a role in treatment outcome.},
  keywords = {{HIV} ; {A}ntiretroviral treatment ; {D}rug resistance ; {S}emi-rural ; {P}ublic health ; {T}ogo ; {A}frica ; {TOGO}},
  booktitle = {},
  journal = {{A}ids {R}esearch and {T}herapy},
  volume = {12},
  numero = {},
  pages = {38 [8 ]},
  ISSN = {1742-6405},
  year = {2015},
  DOI = {10.1186/s12981-015-0082-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065519},
}