@article{fdi:010065518, title = {{A} new 5-alkylresorcinol glucoside derivative from {C}ybianthus magnus}, author = {{C}abanillas, {B}. and {V}asquez-{O}cmin, {P}. and {Z}ebiri, {I}. and {R}engifo, {E}. and {S}auvain, {M}ichel and {L}e, {H}. {L}. and {V}aisberg, {A}. and {V}outquenne-{N}azabadioko, {L}. and {H}addad, {M}ohamed}, editor = {}, language = {{ENG}}, abstract = {{O}ne new 5-alkylresorcinol glucoside (1) was isolated from leaves of {C}ybianthus magnus, along with 12 known compounds, isolated from four plants belonging to {M}yrsinaceae family (2, 3 isolated from {C}. magnus; 4-7, 10 and 11 isolated from {M}yrsine latifolia; 4, 8 and 9 isolated from {M}yrsine sessiflora; 6, 7, 10, 12 and 13 isolated from {M}yrsine congesta). {T}heir structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. {S}o far, only nine 5-alkylresorcinol glucosides were isolated from leaves of {G}revillea robusta. {S}ince resorcinols are known to exhibit strong cytotoxic activity, compounds 1 and 2 were tested against cell lines 3{T}3, {H}460, {DU}145 and {MCF}-7 for cytotoxicity in vitro and compounds 3-13 were tested for their antileishmanial activity. {C}ompound 2 displayed a strong cytotoxic activity with {IC}50 values ranging between 22 and 100{M} for all tested cell lines. {C}ompounds 3-13 were not active against {L}eishmania amazonensis amastigotes.}, keywords = {alkylresorcinol ; secondary metabolites ; {M}yrsinaceae ; anti-leishmaniasis ; cytotoxicity ; {PEROU} ; {AMAZONIE}}, booktitle = {}, journal = {{N}atural {P}roduct {R}esearch}, volume = {30}, numero = {3}, pages = {293--298}, ISSN = {1478-6419}, year = {2016}, DOI = {10.1080/14786419.2015.1056188}, URL = {https://www.documentation.ird.fr/hor/fdi:010065518}, }