@article{fdi:010065512,
  title = {{C}arbon stable isotope analysis of methylmercury toxin in biological materials by gas chromatography isotope ratio mass spectrometry},
  author = {{M}asbou, {J}. and {P}oint, {D}avid and {G}uillou, {G}. and {S}onke, {J}. {E}. and {L}ebreton, {B}. and {R}ichard, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} critical component of the biogeochemical cycle of mercury ({H}g) is the transformation of inorganic {H}g to neurotoxic monomethylmercury ({CH}3{H}g). {H}umans are exposed to {CH}3{H}g by consuming marine fish, yet the origin of {CH}3{H}g in fish is a topic of debate. {T}he carbon stable isotopic composition (delta {C}-13) embedded in the methyl group of {CH}3{H}g remains unexplored. {T}his new isotopic information at the molecular level is thought to represent a new proxy to trace the carbon source at the origin of {CH}3{H}g. {H}ere, we present a compound-specific stable isotope analysis ({CSIA}) technique for the determination of the delta {C}-13 value of {CH}3{H}g in biological samples by gas chromatography combustion isotope ratio mass spectrometry analysis ({GC}-{C}-{IRMS}). {T}he method consists first of calibrating a {CH}3{H}g standard solution for delta {C}-13 {CSIA}. {T}his was achieved by comparing three independent approaches consisting of the derivatization and halogenation of the {CH}3{H}g standard solution. {T}he determination of delta({CCH}3{H}g)-{C}-13 values on natural biological samples was performed by combining a {CH}3{H}g selective extraction, purification, and halogenation followed by {GC}-{C}-{IRMS} analysis. {R}eference delta {C}-13 values were established for a tuna fish certified material ({ERM}-{CE}464) originating from the {A}driatic {S}ea (delta({CCH}3{H}g)-{C}-13 = -22.1 +/- 1.5 +/- 2 {SD}). {T}his value is similar to the delta {C}-13 value of marine algal-derived particulate organic carbon (delta({CPOC})-{C}-13 = -21 parts per thousand).},
  keywords = {},
  booktitle = {},
  journal = {{A}nalytical {C}hemistry},
  volume = {87},
  numero = {23},
  pages = {11732--11738},
  ISSN = {0003-2700},
  year = {2015},
  DOI = {10.1021/acs.analchem.5b02918},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065512},
}