@article{fdi:010065502,
  title = {{I}nfants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with {P}lasmodium falciparum},
  author = {{N}ouatin, {O}. and {G}bedande, {K}. and {I}bitokou, {S}. and {V}ianou, {B}. and {H}oungbegnon, {P}. and {E}zinmegnon, {S}. and {B}orgella, {S}ophie and {A}kplogan, {C}. and {C}ottrell, {G}illes and {V}arani, {S}. and {M}assougbodji, {A}. and {M}outairou, {K}. and {T}roye-{B}lomberg, {M}. and {D}eloron, {P}hilippe and {L}uty, {A}drian and {F}ievet, {N}adine},
  editor = {},
  language = {{ENG}},
  abstract = {{M}aternal parasitoses modulate fetal immune development, manifesting as altered cellular immunological activity in cord blood that may be linked to enhanced susceptibility to infections in early life. {P}lasmodium falciparum typifies such infections, with distinct placental infection-related changes in cord blood exemplified by expanded populations of parasite antigen-specific regulatory {T} cells. {H}ere we addressed whether such early-onset cellular immunological alterations persist through infancy. {S}pecifically, in order to assess the potential impacts of {P}. falciparum infections either during pregnancy or during infancy, we quantified lymphocyte subsets in cord blood and in infants' peripheral blood during the first year of life. {T}he principal age-related changes observed, independent of infection status, concerned decreases in the frequencies of {CD}4(+), {NK}dim and {NKT} cells, whilst {CD}8(+), {T}reg and {T}eff cells' frequencies increased from birth to 12 months of age. {P}. falciparum infections present at delivery, but not those earlier in gestation, were associated with increased frequencies of {T}reg and {CD}8(+) {T} cells but fewer {CD}4(+) and {NKT} cells during infancy, thus accentuating the observed age-related patterns. {O}verall, {P}. falciparum infections arising during infancy were associated with a reversal of the trends associated with maternal infection i.e. with more {CD}4(+) cells, with fewer {T}reg and {CD}8(+) cells. {W}e conclude that maternal {P}. falciparum infection at delivery has significant and, in some cases, year-long effects on the composition of infants' peripheral blood lymphocyte populations. {T}hose effects are superimposed on separate and independent age-as well as infant infection-related alterations that, respectively, either match or run counter to them.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {10},
  numero = {11},
  pages = {e0139606 [23 p.]},
  ISSN = {1932-6203},
  year = {2015},
  DOI = {10.1371/journal.pone.0139606},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065502},
}