@article{fdi:010065483,
  title = {{T}rypanosoma cruzi population dynamics in the {C}entral {E}cuadorian {C}oast},
  author = {{C}ostales, {J}. {A}. and {J}ara-{P}alacios, {M}. {A}. and {L}lewellyn, {M}. {S}. and {M}essenger, {L}. {A}. and {O}cana-{M}ayorga, {S}. and {V}illacis, {A}. {G}. and {T}ibayrenc, {M}ichel and {G}rijalva, {M}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}hagas disease is the most important parasitic disease in {L}atin {A}merica. {T}he causative agent, {T}rypanosoma cruzi, displays high genetic diversity and circulates in complex transmission cycles among domestic, peridomestic and sylvatic environments. {I}n {E}cuador, {R}hodnius ecuadoriensis is known to be the major vector species implicated in {T}. cruzi transmission. {H}owever, across vast areas of {E}cuador, little is known about {T}. cruzi genetic diversity in relation to different parasite transmission scenarios. {F}ifty-eight {T}. cruzi stocks from the central {E}cuadorian coast, most of them derived from {R}. ecuadoriensis, were included in the study. {A}ll of them were genotyped as {T}. cruzi discrete typing unit {I} ({DTU} {T}cl). {A}nalysis of 23 polymorphic microsatellite loci through neighbor joining and discriminant analysis of principal components yielded broadly congruent results and indicate genetic subdivision between sylvatic and peridomestic transmission cycles. {H}owever, both analyses also suggest that any barriers are imperfect and significant gene flow between parasite subpopulations in different habitats exists. {A}lso consistent with moderate partition and residual gene flow between subpopulations, the fixation index ({F}-{ST}) was significant, but of low magnitude. {F}inally, the lack of private alleles in the domestic/peridomestic transmission cycle suggests the sylvatic strains constitute the ancestral population. {T}he {T}. cruzi population in the central {E}cuadorian coast shows moderate tendency to subdivision according to transmission cycle. {H}owever, connectivity between cycles exists and the sylvatic {T}. cruzi population harbored by{R}. ecuadoriensis vectors appears to constitute a source from which the parasite invades human domiciles and their surroundings in this region. {W}e discuss the implications these findings have for the planning, implementation and evaluation of local {C}hagas disease control interventions.},
  keywords = {{T}rypanosoma cruzi ; {R}hodnius ecuadoriensis ; {C}hagas disease ; microsatellite ; {T}ransmission cycle ; {DAPC} ; {E}cuador ; {EQUATEUR}},
  booktitle = {{E}cology and diversity of {T}rypanosoma cruzi},
  journal = {{A}cta {T}ropica},
  volume = {151},
  numero = {},
  pages = {88--93},
  ISSN = {0001-706{X}},
  year = {2015},
  DOI = {10.1016/j.actatropica.2015.07.017},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065483},
}