@article{fdi:010065482,
  title = {{T}he population genetics of {T}rypanosoma cruzi revisited in the light of the predominant clonal evolution model},
  author = {{T}ibayrenc, {M}ichel and {A}yala, {F}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}omparing the population structure of {T}rypanosoma cruzi with that of other pathogens, including parasitic protozoa, fungi, bacteria and viruses, shows that the agent of {C}hagas disease shares typical traits with many other species, related to a predominant clonal evolution ({PCE}) pattern: statistically significant linkage disequilibrium, overrepresented multilocus genotypes, near-clades (genetic subdivisions somewhat blurred by occasional genetic exchange/hybridization) and "{R}ussian doll" patterns ({PCE} is observed, not only at the level of the whole species, but also, within the near-clades). {M}oreover, {T}. cruzi population structure exhibits linkage with the diversity of several strongly selected genes, with gene expression profiles, and with some major phenotypic traits. {W}e discuss the evolutionary significance of these results, and their implications in terms of applied research (molecular epidemiology/strain typing, analysis of genes of interest, vaccine and drug design, immunological diagnosis) and of experimental evolution. {L}astly, we revisit the long-term debate of describing new species within the {T}. cruzi taxon.},
  keywords = {{P}redominant clonal evolution ; {N}ear-clade ; {D}iscrete typing unit ; {R}ecombinational load ; {D}rug resistance ; {AMERIQUE} {LATINE}},
  booktitle = {{E}cology and diversity of {T}rypanosoma cruzi},
  journal = {{A}cta {T}ropica},
  volume = {151},
  numero = {},
  pages = {156--165},
  ISSN = {0001-706{X}},
  year = {2015},
  DOI = {10.1016/j.actatropica.2015.05.006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065482},
}