%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Olson, S. C.
%A Ngo-Giang-Huong, Nicole
%A Beck, I.
%A Deng, W. J.
%A Britto, P.
%A Shapiro, D. E.
%A Bumgarner, R. E.
%A Mullins, J. I.
%A Van Dyke, R. B.
%A Jourdain, Gonzague
%A Frenkel, L. M.
%T Resistance detected by pyrosequencing following zidovudine monotherapy for prevention of HIV-1 mother-to-child-transmission
%D 2015
%L fdi:010065442
%G ENG
%J Aids
%@ 0269-9370
%K HIV-1 ; mother-to-child-transmission ; prophylaxis ; pyrosequencing ; resistance ; zidovudine
%K THAILANDE
%M ISI:000364394500002
%N 12
%P 1467-1471
%R 10.1097/qad.0000000000000737
%U https://www.documentation.ird.fr/hor/fdi:010065442
%> https://www.documentation.ird.fr/intranet/publi/2015/12/010065442.pdf
%V 29
%W Horizon (IRD)
%X To prevent mother-to-child-transmission of HIV-1, the 2010 WHO guidelines recommended prenatal zidovudine (ZDV) monotherapy (option A). To determine if ZDV monotherapy selects for HIV resistance in antiretroviral-naive women during pregnancy, specimens from 50 individuals were examined using pyrosequencing. ZDV-resistance mutations were detected at delivery in seven women (14%, 95% confidence interval 6.6-26.5%). These data raise the question whether women administered ZDV monotherapy for prevention of mother-to-child-transmission could have higher risk of virologic failure when later started on combination antiretroviral therapy, as has been demonstrated following single-dose nevirapine prophylaxis.
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