@article{fdi:010065435,
  title = {{E}valuation of the preclinical efficacy of four antivenoms, distributed in sub-{S}aharan {A}frica, to neutralize the venom of the carpet viper, {E}chis ocellatus, from {M}ali, {C}ameroon, and {N}igeria},
  author = {{S}anchez, {L}. {V}. and {P}la, {D}. and {H}errera, {M}. and {C}hippaux, {J}ean-{P}hilippe and {C}alvete, {J}. {J}. and {G}utierrez, {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}nakebite envenoming causes a heavy toll in sub-{S}aharan {A}frica in terms of mortality and sequelae. {I}n the {W}est {A}frican savannah, the viperid {E}chis ocellatus is responsible for the vast majority of bites. {I}n the last decades, several new antivenoms have been introduced for the treatment of these envenomings, although the assessment of their preclinical efficacy against the venom of {E}. ocellatus has been studied only for some of them. {T}his work analyzed comparatively the ability of four antivenoms ({FAV} {A}frique, {E}chi{TA}b {G}, {E}chi{TAB}-{P}lus-{ICP} ({R}), and {I}noserp ({TM}) {P}anafricain) to neutralize lethal, hemorrhagic, and in vitro coagulant activities of the venoms of {E}. ocellatus from {M}ali, {C}ameroon, and {N}igeria. {I}n addition, an immunoaffinity chromatography antivenomic protocol was used to assess the ability of the four antivenoms to bind to the proteins of these venoms. {R}esults showed that all the antivenoms were effective in the neutralization of the three effects investigated, and were able to immunocapture, completely or partially, the most abundant components in the {E}. ocellatus venoms from the geographical origins sampled. {O}ur observations also highlighted quantitative differences between antivenoms in their neutralizing and antivenomics profiles, especially regarding neutralization of in vitro coagulant activity, suggesting that different doses of these antivenoms are probably needed for an effective treatment of human envenomings by this species.},
  keywords = {{E}chis ocellatus ; {A}ntivenom ; {H}emorrhage ; {L}ethality ; {P}rocoagulant effect ; {N}eutralization ; {A}ntivenomics ; {MALI} ; {CAMEROUN} ; {NIGERIA}},
  booktitle = {},
  journal = {{T}oxicon},
  volume = {106},
  numero = {},
  pages = {97--107},
  ISSN = {0041-0101},
  year = {2015},
  DOI = {10.1016/j.toxicon.2015.09.027},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065435},
}