@article{fdi:010065419,
  title = {{M}onoclonal gammopathy in {HIV}-1-infected patients : factors associated with disappearance under long-term antiretroviral therapy},
  author = {{C}asanova, {M}. {L}. and {M}akinson, {A}. and {E}ymard-{D}uvernay, {S}abrina and {O}uedraogo, {D}. {E}. and {B}adiou, {S}. and {R}eynes, {J}. and {T}uaillon, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective:{M}onoclonal gammopathies ({MG}s) associated with {HIV} infection are frequent but their evolution and significance are uncertain in this population at high risk of lymphoproliferative disorder. {O}ur aim was to describe the long-term evolution of {MG} in {HIV}-infected subjects under antiretroviral therapy.{M}ethods:{R}etrospective study of {HIV}-1-infected adults, with a monoclonal ({M}) protein detected by serum protein electrophoresis and confirmed by immunofixation. {L}ogistic regression was used to analyze factors associated with peak disappearance.{R}esults:{B}etween {S}eptember 1997 and {N}ovember 2012, 1219 serum protein electrophoreses were performed on our {HIV} cohort, and 137 (11.3%) {MG}s were detected. {S}eventy-seven subjects met the inclusion criteria: 68% male, median age 41 years, 47% {AIDS} stage, median {CD}4 count 237 per cubic millimeter, 81% uncontrolled {HIV} infection with {HIV} viral load over 400 copies per milliliter, 32% chronic hepatitis {C}, and 9% chronic hepatitis {B}. {E}ighteen subjects were not included because of previous or concomitant hemopathy. {W}ith a median follow-up of 6.8 years (interquartile range, 3.9-9.1), 66.2% of subjects showed a peak disappearance. {I}n multivariate analysis, {MG} disappearance was associated with {HIV} virologic control (odds ratio, 5.98; 95% confidence interval: 1.63 to 21.87; {P} = 0.007) and the absence of hepatitis {C} virus replication at the end of follow-up (odds ratio, 10.16; 95% confidence interval: 2.36 to 43.69; {P} = 0.002). {O}ne subject developed a myeloma 3 years after the diagnosis of an {I}g{A} kappa {MG}.{C}onclusions:{MG} associated with {HIV} infection concerned a young population and had favorable evolution on antiretroviral therapy in most cases. {M} protein disappearance was associated with {HIV} virologic control and the absence of chronic hepatitis {C} virus.},
  keywords = {monoclonal gammopathy ; {HIV} infection ; antiretroviral therapy ; {HAART} ; lymphoproliferative disorder},
  booktitle = {},
  journal = {{J}aids-{J}ournal of {A}cquired {I}mmune {D}eficiency {S}yndromes},
  volume = {70},
  numero = {3},
  pages = {250--255},
  ISSN = {1525-4135},
  year = {2015},
  DOI = {10.1097/qai.0000000000000708},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065419},
}