%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Hoa, L. N. M.
%A Bryant, J. E.
%A Choisy, Marc
%A Nguyet, L. A.
%A Bao, N. T.
%A Trang, N. H.
%A Chuc, N. T. K.
%A Toan, T. K.
%A Saito, T.
%A Takemae, N.
%A Horby, P.
%A Wertheim, H.
%A Fox, A.
%T Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012
%D 2015
%L fdi:010065387
%G ENG
%J Epidemiology and Infection
%@ 0950-2688
%K Influenza A ; virology (human) and epidemiology ; zoonoses
%K VIET NAM
%M ISI:000362955500005
%N 14
%P 2959-2964
%R 10.1017/s0950268815000187
%U https://www.documentation.ird.fr/hor/fdi:010065387
%> https://www.documentation.ird.fr/intranet/publi/2015/11/010065387.pdf
%V 143
%W Horizon (IRD)
%X A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI >= 40) was high and similar for both viruses, with 62.6% [95% confidence interval (CI) 59.4-65.7] against A/Perth/16/2009 and 54.6% (95% CI 51.4-57.8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
%$ 052