Publications des scientifiques de l'IRD

Hoa L. N. M., Bryant J. E., Choisy Marc, Nguyet L. A., Bao N. T., Trang N. H., Chuc N. T. K., Toan T. K., Saito T., Takemae N., Horby P., Wertheim H., Fox A. (2015). Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012. Epidemiology and Infection, 143 (14), p. 2959-2964. ISSN 0950-2688.

Titre du document
Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000362955500005
Auteurs
Hoa L. N. M., Bryant J. E., Choisy Marc, Nguyet L. A., Bao N. T., Trang N. H., Chuc N. T. K., Toan T. K., Saito T., Takemae N., Horby P., Wertheim H., Fox A.
Source
Epidemiology and Infection, 2015, 143 (14), p. 2959-2964 ISSN 0950-2688
A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI >= 40) was high and similar for both viruses, with 62.6% [95% confidence interval (CI) 59.4-65.7] against A/Perth/16/2009 and 54.6% (95% CI 51.4-57.8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
VIET NAM
Localisation
Fonds IRD [F B010065387]
Identifiant IRD
fdi:010065387
Contact