@article{fdi:010065384,
  title = {{I}nclusion of gametocyte parameters in anti-malarial drug efficacy studies : filling a neglected gap needed for malaria elimination},
  author = {{A}bdul-{G}hani, {R}. and {B}asco, {L}eonardo and {B}eier, {J}. {C}. and {M}ahdy, {M}. {A}. {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}tandard anti-malarial drug efficacy and drug resistance assessments neglect the gametocyte parameters in their protocols. {W}ith the spread of drug resistance and the absence of clinically proven vaccines, the use of gametocytocidal drugs or drug combinations with transmission-blocking activity is a high priority for malaria control and elimination. {H}owever, the limited repertoire of gametocytocidal drugs and induction of gametocytogenesis after treatment with certain anti-malarial drugs necessitate both regular monitoring of gametocytocidal activities of anti-malarial drugs in clinical use and the effectiveness of candidate gametocytocidal agents. {T}herefore, updating current protocols of antimalarial drug efficacy is needed to reflect the effects of anti-malarial drugs or drug combinations on gametocyte carriage and gametocyte density along with asexual parasite density. {D}eveloping protocols of anti-malarial drug efficacy that include gametocyte parameters related to both microscopic and submicroscopic gametocytaemias is important if drugs or drug combinations are to be strategically used in transmission-blocking interventions in the context of malaria elimination. {T}he present piece of opinion highlights the challenges in gametocyte detection and follow-up and discuss the need for including the gametocyte parameter in anti-malarial efficacy studies.},
  keywords = {{P}lasmodium ; {G}ametocyte ; {A}nti-malarial drug ; {D}rug resistance ; {E}fficacy study ; {M}alaria elimination},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {14},
  numero = {},
  pages = {art. 413 [6 p.]},
  ISSN = {1475-2875},
  year = {2015},
  DOI = {10.1186/s12936-015-0936-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065384},
}