Publications des scientifiques de l'IRD

Abdul-Ghani R., Basco Leonardo, Beier J. C., Mahdy M. A. K. (2015). Inclusion of gametocyte parameters in anti-malarial drug efficacy studies : filling a neglected gap needed for malaria elimination. Malaria Journal, 14, p. art. 413 [6 p.]. ISSN 1475-2875.

Titre du document
Inclusion of gametocyte parameters in anti-malarial drug efficacy studies : filling a neglected gap needed for malaria elimination
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000363009600003
Auteurs
Abdul-Ghani R., Basco Leonardo, Beier J. C., Mahdy M. A. K.
Source
Malaria Journal, 2015, 14, p. art. 413 [6 p.] ISSN 1475-2875
Standard anti-malarial drug efficacy and drug resistance assessments neglect the gametocyte parameters in their protocols. With the spread of drug resistance and the absence of clinically proven vaccines, the use of gametocytocidal drugs or drug combinations with transmission-blocking activity is a high priority for malaria control and elimination. However, the limited repertoire of gametocytocidal drugs and induction of gametocytogenesis after treatment with certain anti-malarial drugs necessitate both regular monitoring of gametocytocidal activities of anti-malarial drugs in clinical use and the effectiveness of candidate gametocytocidal agents. Therefore, updating current protocols of antimalarial drug efficacy is needed to reflect the effects of anti-malarial drugs or drug combinations on gametocyte carriage and gametocyte density along with asexual parasite density. Developing protocols of anti-malarial drug efficacy that include gametocyte parameters related to both microscopic and submicroscopic gametocytaemias is important if drugs or drug combinations are to be strategically used in transmission-blocking interventions in the context of malaria elimination. The present piece of opinion highlights the challenges in gametocyte detection and follow-up and discuss the need for including the gametocyte parameter in anti-malarial efficacy studies.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010065384]
Identifiant IRD
fdi:010065384
Contact