@article{fdi:010065375,
  title = {{G}enetic diversity of {P}lasmodium falciparum isolates from {B}aka {P}ygmies and their {B}antu neighbours in the north of {G}abon},
  author = {{M}ve-{O}ndo, {B}. and {N}koghe, {D}. and {A}rnathau, {C}. and {R}ougeron, {V}. and {B}isvigou, {U}. and {M}ouele, {L}. {Y}. and {B}oundenga, {L}. and {D}urand, {P}. and {E}lguero, {E}ric and {L}emmers, {S}. and {D}elicat-{L}oembet, {L}. {M}. and {D}iamella-{M}oukodoum, {N}. and {P}aupy, {C}hristophe and {R}enaud, {F}. and {P}rugnolle, {F}ranck and {O}llomo, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}here have been many reports on the population genetic structure of {P}lasmodium falciparum from different endemic regions especially sub-{S}aharan {A}frica. {H}owever, few studies have been performed on neglected populations, such as the {P}ygmy populations. {I}n this study, the population genetic structure of {P}. falciparum was investigated in the {B}aka {P}ygmies of {G}abon and compared to that observed in neighboring villages composed mostly of {B}antu farmers. {M}ethods: {A} total of 342 blood samples were collected from 170 {B}aka {P}ygmies and 172 {B}antus in the north of {G}abon ({W}oleu {N}tem {P}rovince). {P}lasmodium infections were characterized by sequencing a portion of the parasite cytochrome b gene. {P}opulation genetic structure of {P}. falciparum in the different villages was analysed using microsatellite markers and genes coding for antigenic proteins ({MSP}1, {MSP}2, {GLURP}, and {EBA}-175). {R}esults: {O}verall, prevalence of {P}. falciparum was around 57 % and no significant difference of prevalence was observed between {P}ygmies and {B}antus. {N}o significant differences of population genetic structure of {P}. falciparum was found between {P}ygmy and {B}antu people except for one antigen-coding gene, glurp, for which genetic data suggested the existence of a potentially disruptive selection acting on this gene in the two types of populations. {T}he genetic structure of {P}. falciparum followed a pattern of isolation by distance at the scale of the study. {C}onclusion: {T}he prevalence and genetic diversity of {P}. falciparum observed in {B}aka demonstrates a significant transmission of the parasite in this population, and some exchanges of parasites with {B}antu neighbours. {D}espite that, some antigen-coding genes seem to have had a particular evolutionary trajectory in certain {P}ygmy populations due to specific local human and/or mosquito characteristics.},
  keywords = {{M}alaria ; {G}enetic diversity ; {P}opulation structure ; {M}icrosatellite loci ; {A}ntigenic determinants ; {B}aka {P}ygmies ; {B}antus ; {GABON}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {14},
  numero = {},
  pages = {art. 395 [11 p.]},
  ISSN = {1475-2875},
  year = {2015},
  DOI = {10.1186/s12936-015-0862-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065375},
}