@article{fdi:010065355,
  title = {{I}dentification of a major dimorphic region in the functionally critical {N}-terminal {ID}1 domain of {VAR}2{CSA}},
  author = {{D}oritchamou, {J}. and {S}abbagh, {A}. and {J}espersen, {J}. {S}. and {R}enard, {E}. and {S}alanti, {A}. and {N}ielsen, {M}. {A}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {VAR}2{CSA} protein of {P}lasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria ({PM}). {I}t is the current leading candidate for a vaccine to prevent {PM}. {H}owever, the antigenic polymorphism integral to {VAR}2{CSA} poses a challenge for vaccine development. {B}ased on detailed analysis of polymorphisms in the sequence of its ligand-binding {N}-terminal region, currently the main focus for vaccine development, we assessed var2csa from parasite isolates infecting pregnant women. {T}he results reveal for the first time the presence of a major dimorphic region in the functionally critical {N}-terminal {ID}1 domain. {P}arasite isolates expressing {VAR}2{CSA} with particular motifs present within this domain are associated with gravidity-and parasite density-related effects. {T}hese observations are of particular interest in guiding efforts with respect to optimization of the {VAR}2{CSA}-based vaccines currently under development.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {10},
  numero = {9},
  pages = {e0137695 [14 p.]},
  ISSN = {1932-6203},
  year = {2015},
  DOI = {10.1371/journal.pone.0137695},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065355},
}