Publications des scientifiques de l'IRD

Doritchamou J., Sabbagh A., Jespersen J. S., Renard E., Salanti A., Nielsen M. A., Deloron Philippe, Tuikue Ndam Nicaise. (2015). Identification of a major dimorphic region in the functionally critical N-terminal ID1 domain of VAR2CSA. Plos One, 10 (9), p. e0137695 [14 p.]. ISSN 1932-6203.

Titre du document
Identification of a major dimorphic region in the functionally critical N-terminal ID1 domain of VAR2CSA
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000361792100016
Auteurs
Doritchamou J., Sabbagh A., Jespersen J. S., Renard E., Salanti A., Nielsen M. A., Deloron Philippe, Tuikue Ndam Nicaise
Source
Plos One, 2015, 10 (9), p. e0137695 [14 p.] ISSN 1932-6203
The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the current leading candidate for a vaccine to prevent PM. However, the antigenic polymorphism integral to VAR2CSA poses a challenge for vaccine development. Based on detailed analysis of polymorphisms in the sequence of its ligand-binding N-terminal region, currently the main focus for vaccine development, we assessed var2csa from parasite isolates infecting pregnant women. The results reveal for the first time the presence of a major dimorphic region in the functionally critical N-terminal ID1 domain. Parasite isolates expressing VAR2CSA with particular motifs present within this domain are associated with gravidity-and parasite density-related effects. These observations are of particular interest in guiding efforts with respect to optimization of the VAR2CSA-based vaccines currently under development.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010065355]
Identifiant IRD
fdi:010065355
Contact