%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Boue, V.
%A Locatelli, Sabrina
%A Boucher, F.
%A Ayouba, Ahidjo
%A Butel, Christelle
%A Esteban, Amandine
%A Okouga, A. P.
%A Ndoungouet, A.
%A Motsch, P.
%A Le Flohic, G.
%A Ngari, P.
%A Prugnolle, Franck
%A Ollomo, B.
%A Rouet, F.
%A Liégeois, Florian
%T High rate of Simian Immunodeficiency Virus (SIV) infections in wild chimpanzees in Northeastern Gabon
%D 2015
%L fdi:010065327
%G ENG
%J Viruses - Basel
%@ 1999-4915
%K Chimpanzee ; SIV ; AIDS ; Africa ; antibody ; microsatellite ; primate ; prevalence ; retrovirus ; transmission
%K GABON
%M ISI:000361762400009
%N 9
%P 4997-5015
%R 10.3390/v7092855
%U https://www.documentation.ird.fr/hor/fdi:010065327
%> https://www.documentation.ird.fr/intranet/publi/2015/10/010065327.pdf
%V 7
%W Horizon (IRD)
%X The emergence of HIV-1 groups M, N, O, and P is the result of four independent cross-species transmissions between chimpanzees (cpz) and gorillas (gor) from central/south Cameroon and humans respectively. Although the first two SIVcpz were identified in wild-born captive chimpanzees in Gabon in 1989, no study has been conducted so far in wild chimpanzees in Gabon. To document the SIVcpz infection rate, genetic diversity, and routes of virus transmission, we analyzed 1458 faecal samples collected in 16 different locations across the country, and we conducted follow-up missions in two of them. We found 380 SIV antibody positive samples in 6 different locations in the north and northeast. We determined the number of individuals collected by microsatellite analysis and obtained an adjusted SIV prevalence of 39.45%. We performed parental analysis to investigate viral spread between and within communities and found that SIVs were epidemiologically linked and were transmitted by both horizontal and vertical routes. We amplified pol and gp41 fragments and obtained 57 new SIVcpzPtt strains from three sites. All strains, but one, clustered together within a specific phylogeographic clade. Given that these SIV positive samples have been collected nearby villages and that humans continue to encroach in ape's territories, the emergence of a new HIV in this area needs to be considered.
%$ 052 ; 080