@article{fdi:010065327,
  title = {{H}igh rate of {S}imian {I}mmunodeficiency {V}irus ({SIV}) infections in wild chimpanzees in {N}ortheastern {G}abon},
  author = {{B}oue, {V}. and {L}ocatelli, {S}abrina and {B}oucher, {F}. and {A}youba, {A}hidjo and {B}utel, {C}hristelle and {E}steban, {A}mandine and {O}kouga, {A}. {P}. and {N}doungouet, {A}. and {M}otsch, {P}. and {L}e {F}lohic, {G}. and {N}gari, {P}. and {P}rugnolle, {F}ranck and {O}llomo, {B}. and {R}ouet, {F}. and {L}i{\'e}geois, {F}lorian},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he emergence of {HIV}-1 groups {M}, {N}, {O}, and {P} is the result of four independent cross-species transmissions between chimpanzees (cpz) and gorillas (gor) from central/south {C}ameroon and humans respectively. {A}lthough the first two {SIV}cpz were identified in wild-born captive chimpanzees in {G}abon in 1989, no study has been conducted so far in wild chimpanzees in {G}abon. {T}o document the {SIV}cpz infection rate, genetic diversity, and routes of virus transmission, we analyzed 1458 faecal samples collected in 16 different locations across the country, and we conducted follow-up missions in two of them. {W}e found 380 {SIV} antibody positive samples in 6 different locations in the north and northeast. {W}e determined the number of individuals collected by microsatellite analysis and obtained an adjusted {SIV} prevalence of 39.45%. {W}e performed parental analysis to investigate viral spread between and within communities and found that {SIV}s were epidemiologically linked and were transmitted by both horizontal and vertical routes. {W}e amplified pol and gp41 fragments and obtained 57 new {SIV}cpz{P}tt strains from three sites. {A}ll strains, but one, clustered together within a specific phylogeographic clade. {G}iven that these {SIV} positive samples have been collected nearby villages and that humans continue to encroach in ape's territories, the emergence of a new {HIV} in this area needs to be considered.},
  keywords = {{C}himpanzee ; {SIV} ; {AIDS} ; {A}frica ; antibody ; microsatellite ; primate ; prevalence ; retrovirus ; transmission ; {GABON}},
  booktitle = {},
  journal = {{V}iruses - {B}asel},
  volume = {7},
  numero = {9},
  pages = {4997--5015},
  ISSN = {1999-4915},
  year = {2015},
  DOI = {10.3390/v7092855},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065327},
}