@article{fdi:010065274,
  title = {{R}educing human-tsetse contact significantly enhances the efficacy of sleeping sickness active screening campaigns : a promising result in the context of elimination},
  author = {{C}ourtin, {F}abrice and {C}amara, {M}. and {R}ayaisse, {J}. {B}. and {K}agbadouno, {M}. and {D}ama, {E}. and {C}amara, {O}. and {T}raore, {I}. {S}. and {R}ouamba, {J}. and {P}eylhard, {M}. and {S}omda, {M}. {B}. and {L}eno, {M}. and {L}ehane, {M}. {J}. and {T}orr, {S}. {J}. and {S}olano, {P}hilippe and {J}amonneau, {V}incent and {B}ucheton, {B}runo},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {C}ontrol of gambiense sleeping sickness, a neglected tropical disease targeted for elimination by 2020, relies mainly on mass screening of populations at risk and treatment of cases. {T}his strategy is however challenged by the existence of undetected reservoirs of parasites that contribute to the maintenance of transmission. {I}n this study, performed in the {B}offa disease focus of {G}uinea, we evaluated the value of adding vector control to medical surveys and measured its impact on disease burden. {M}ethods {T}he focus was divided into two parts (screen and treat in the western part; screen and treat plus vector control in the eastern part) separated by the {R}io {P}ongo river. {P}opulation census and baseline entomological data were collected from the entire focus at the beginning of the study and insecticide impregnated targets were deployed on the eastern bank only. {M}edical surveys were performed in both areas in 2012 and 2013. {F}indings {I}n the vector control area, there was an 80% decrease in tsetse density, resulting in a significant decrease of human tsetse contacts, and a decrease of disease prevalence (from 0.3% to 0.1%; p=0.01), and an almost nil incidence of new infections (<0.1%). {I}n contrast, incidence was 10 times higher in the area without vector control (>1%, p<0.0001) with a disease prevalence increasing slightly (from 0.5 to 0.7%, p=0.34). {I}nterpretation {C}ombining medical and vector control was decisive in reducing {T}. b. gambiense transmission and in speeding up progress towards elimination. {S}imilar strategies could be applied in other foci.},
  keywords = {{GUINEE}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {9},
  numero = {8},
  pages = {e0003727 [12 p.]},
  ISSN = {1935-2735},
  year = {2015},
  DOI = {10.1371/journal.pntd.0003727},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065274},
}