%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ibitokou, S. A.
%A Denoeud Ndam, Lise
%A Ezinmegnon, S.
%A Ladekpo, R.
%A Zannou, D. M.
%A Massougbodji, A.
%A Girard, P. M.
%A Cot, Michel
%A Luty, Adrian
%A Tuikue Ndam, Nicaise
%T Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to Plasmodium falciparum malaria
%D 2015
%L fdi:010064908
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K BENIN
%M ISI:000359327400018
%N 2
%P 287-292
%R 10.4269/ajtmh.14-0653
%U https://www.documentation.ird.fr/hor/fdi:010064908
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010064908.pdf
%V 93
%W Horizon (IRD)
%X We investigated the circulating plasma levels of Th1- (Interleukin-2 [IL-2], tumor necrosis factor-alpha [TNF-alpha], interferon-gamma [IFN-gamma]) and Th2-type (1L-4, IL-5, IL-10) cytokines in human immunodeficiency virus (HIV)-infected pregnant women living in a malaria-endemic area. We analyzed samples from 200 pregnant women included in the prevention of pregnancy-associated malaria in HIV-infected women: cotrimoxazole prophylaxis versus mefloquine (PACOME) clinical trial who were followed until delivery. Cytokine concentrations were measured by flow cytometry-based multiplex bead array. Significantly elevated levels of IL-10 and lower levels of TNF-alpha were observed at delivery compared with inclusion (P = 0.005). At inclusion, the presence of circulating 1FN-gamma, a higher CD4(+) T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. At delivery, the inverse relationship between the presence of infection and circulating IFN-gamma persisted, although there was a positive association between the likelihood of infection and the presence of circulating TNF-alpha. Initiation of antiretroviral therapy was associated with elevated IL-5 production. Consistent with our own and others' observations in HIV seronegative subjects, this study shows circulating IL-10 to be a marker of infection with P. falciparum during pregnancy even in HIV-infected women, although plasma IFN-gamma may be a marker of anti-malarial protection in such women.
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