Publications des scientifiques de l'IRD

Ibitokou S. A., Denoeud Ndam Lise, Ezinmegnon S., Ladekpo R., Zannou D. M., Massougbodji A., Girard P. M., Cot Michel, Luty Adrian, Tuikue Ndam Nicaise. (2015). Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to Plasmodium falciparum malaria. American Journal of Tropical Medicine and Hygiene, 93 (2), p. 287-292. ISSN 0002-9637.

Titre du document
Insights into circulating cytokine dynamics during pregnancy in HIV-infected beninese exposed to Plasmodium falciparum malaria
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000359327400018
Auteurs
Ibitokou S. A., Denoeud Ndam Lise, Ezinmegnon S., Ladekpo R., Zannou D. M., Massougbodji A., Girard P. M., Cot Michel, Luty Adrian, Tuikue Ndam Nicaise
Source
American Journal of Tropical Medicine and Hygiene, 2015, 93 (2), p. 287-292 ISSN 0002-9637
We investigated the circulating plasma levels of Th1- (Interleukin-2 [IL-2], tumor necrosis factor-alpha [TNF-alpha], interferon-gamma [IFN-gamma]) and Th2-type (1L-4, IL-5, IL-10) cytokines in human immunodeficiency virus (HIV)-infected pregnant women living in a malaria-endemic area. We analyzed samples from 200 pregnant women included in the prevention of pregnancy-associated malaria in HIV-infected women: cotrimoxazole prophylaxis versus mefloquine (PACOME) clinical trial who were followed until delivery. Cytokine concentrations were measured by flow cytometry-based multiplex bead array. Significantly elevated levels of IL-10 and lower levels of TNF-alpha were observed at delivery compared with inclusion (P = 0.005). At inclusion, the presence of circulating 1FN-gamma, a higher CD4(+) T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. At delivery, the inverse relationship between the presence of infection and circulating IFN-gamma persisted, although there was a positive association between the likelihood of infection and the presence of circulating TNF-alpha. Initiation of antiretroviral therapy was associated with elevated IL-5 production. Consistent with our own and others' observations in HIV seronegative subjects, this study shows circulating IL-10 to be a marker of infection with P. falciparum during pregnancy even in HIV-infected women, although plasma IFN-gamma may be a marker of anti-malarial protection in such women.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010064908]
Identifiant IRD
fdi:010064908
Contact