@article{fdi:010064902,
  title = {{M}icro {RNA} expression profiles in peripheral blood cells of rats that were experimentally infected with {T}rypanosoma congolense and different {T}rypanosoma brucei subspecies},
  author = {{S}imo, {G}. and {L}ueong, {S}. and {G}r{\'e}baut, {P}ascal and {C}uny, {G}{\'e}rard and {H}oheisel, {J}. {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o identify mi{RNA}s whose expression are differentially regulated during trypanosome infections a microarray targeting more than 600 rat mi{RNA} was used to analyze the mi{RNA} expression profiles between uninfected rats and animals infected by {T}rypanosoma congolense and {T}rypanosoma brucei s.l. {T}he potential targets of dysregulated mi{RNA}s as well as their biological pathways and functions were predicted using several bioinformatics software tools. {I}rrespective of the infecting trypanosome species, eight mi{RNA}s (seven up- and one down-regulated) were dysregulated during infections. {M}oreover, other mi{RNA}s were differentially regulated in rats infected by specific trypanosome species. {F}unctional analyses of differentially regulated mi{RNA}s indicated their involvement in diverse biological processes. {A}mong these, transcription repressor activity, gene expression control as well as protein transporter activity were predominant. {G}ene {O}ntology and {K}yoto {E}ncyclopedia of {G}enes and {G}enomes analysis of dysregulated mi{RNA}s revealed their involvement in several biological pathways and disease conditions. {T}his suggests possible modulation of such pathways following trypanosome infection; for example, the {MAPK} signaling pathway which is known to play vital roles in apoptosis, innate immune response and response to viral infections was highly affected. {A}xon guidance was equally highly impacted and may indicate a cross reactivity between pathogen proteins and guidance molecules representing one pathological mechanism as it has been observed with influenza {HA}. {F}urthermore, {I}ngenuity pathway analyses of dysregulated mi{RNA}s and potential targets indicated strong association with inflammatory responses, cell death and survival as well as infectious diseases. {T}he data generated here provide valuable information to understand the regulatory function of mi{RNA}s during trypanosome infections. {T}hey improved our knowledge on host-parasite cross-talks and provide a framework for investigations to understand the development of trypanosomes in their hosts as well as the differences in the clinical and pathological evolutions of the disease.},
  keywords = {mi{RNA} ; {T}rypanosoma brucei ; {T}typanosoma congolense ; {R}at ; {M}icroarrays ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{M}icrobes and {I}nfection},
  volume = {17},
  numero = {8},
  pages = {596--608},
  ISSN = {1286-4579},
  year = {2015},
  DOI = {10.1016/j.micinf.2015.03.004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064902},
}