@article{fdi:010064872,
  title = {{M}or{TAL} {K}ombat : the story of defense against {TAL} effectors through loss-of-susceptibility [plus corrigendum]},
  author = {{H}utin, {M}. and {P}erez-{Q}uintero, {A}. {L}. and {L}opez, {C}. and {S}zurek, {B}oris},
  editor = {},
  language = {{ENG}},
  abstract = {{M}any plant-pathogenic xanthomonads rely on {T}ranscription {A}ctivator-{L}ike ({TAL}) effectors to colonize their host. {T}his particular family of type {I}ll effectors functions as specific plant transcription factors via a programmable {DNA}-binding domain. {U}pon binding to the promoters of plant disease susceptibility genes in a sequence-specific manner, the expression of these host genes is induced. {H}owever, plants have evolved specific strategies to counter the action of {TAL} effectors and confer resistance. {O}ne mechanism is to avoid the binding of {TAL} effectors by mutations of their {DNA} binding sites, resulting in resistance by loss-of-susceptibility. {T}his article reviews our current knowledge of the susceptibility hubs targeted by {X}anthomonas {TAL} effectors, possible evolutionary scenarios for plants to combat the pathogen with loss-of-function alleles, and how this knowledge can be used overall to develop new pathogen-informed breeding strategies and improve crop resistance.},
  keywords = {{X}anthomonas ; plant disease susceptibility {S} genes ; hubs ; {TAL} effectors ; agricultural biotechnology ; loss-of-function alleles},
  booktitle = {},
  journal = {{F}rontiers in {P}lant {S}cience},
  volume = {6},
  numero = {},
  pages = {art. 535 [12 ] + corrigendum art. 647 [1 p.]},
  ISSN = {1664-462{X}},
  year = {2015},
  DOI = {10.3389/fpls.2015.00535},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064872},
}