@article{fdi:010064867,
  title = {{P}ilot study on the combination of an organophosphate-based insecticide paint and pyrethroid-treated long lasting nets against pyrethroid resistant malaria vectors in {B}urkina {F}aso},
  author = {{M}osqueira, {B}. and {S}oma, {D}. {D}. and {N}amountougou, {M}. and {P}oda, {S}. and {D}iabat{\'e}, {A}. and {A}li, {O}. and {F}ournet, {F}lorence and {B}aldet, {T}. and {C}arnevale, {P}. and {D}abir{\'e}, {R}. {K}. and {M}as-{C}oma, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} pilot study to test the efficacy of combining an organophosphate-based insecticide paint and pyrethroid-treated {L}ong {L}asting {I}nsecticide {T}reated {N}ets ({LLIN}s) against pyrethroid-resistant malaria vector mosquitoes was performed in a real village setting in {B}urkina {F}aso. {P}aint {I}nesfly 5{A} {IGR} ({TM}), comprised of two organophosphates ({OP}s) and an {I}nsect {G}rowth {R}egulator ({IGR}), was tested in combination with pyrethroid-treated {LLIN}s. {E}fficacy was assessed in terms of mortality for 12 months using {E}arly {M}orning {C}ollections of malaria vectors and 30-minute {WHO} bioassays. {R}esistance to pyrethroids and {OP}s was assessed by detecting the frequency of {L}1014{F} and {L}1014{S} kdr mutations and {A}ce-{I}({R}){G}119{S} mutation, respectively. {B}lood meal origin was identified using a direct enzyme-linked immunosorbent assay ({ELISA}). {T}he combination of {I}nesfly 5{A} {IGR} ({TM}) and {LLIN}s was effective in killing 99.9-100% of malaria vector populations for 6 months regardless of the dose and volume treated. {A}fter 12 months, mortality rates decreased to 69.5-82.2%. {T}he highest mortality rates observed in houses treated with 2 layers of insecticide paint and a larger volume. {WHO} bioassays supported these results: mortalities were 98.8-100% for 6 months and decreased after 12 months to 81.7-97.0%. {M}ortality rates in control houses with {LLIN}s were low. {C}ollected malaria vectors consisted exclusively of {A}nopheles coluzzii and were resistant to pyrethroids, with a {L}1014 kdr mutation frequency ranging from 60 to 98% through the study. {A}bout 58% of {A}n. coluzzii collected inside houses had bloodfed on non-human animals. {C}ombining {I}nesfly 5{A} {IGR} ({TM}) and {LLIN}s yielded a one year killing efficacy against {A}n. coluzzii highly resistant to pyrethroids but susceptible to {OP}s that exhibited an anthropo-zoophilic behaviour in the study area. {T}he results obtained in a real setting supported previous work performed in experimental huts and underscore the need to study the impact that this novel strategy may have on clinical malaria and malaria exposure in children in a similar area of high pyrethroid resistance in {S}outh-{W}estern {B}urkina {F}aso.},
  keywords = {{I}nesfly 5{A} {IGR} ({TM}) ; {LLIN}s ; {P}yrethroid resistance ; {A}nopheles coluzzii ; {M}alaria control ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {148},
  numero = {},
  pages = {162--169},
  ISSN = {0001-706{X}},
  year = {2015},
  DOI = {10.1016/j.actatropica.2015.04.010},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064867},
}