@article{fdi:010064790,
  title = {{I}nference of the {A}rabidopsis lateral root gene regulatory network suggests a bifurcation mechanism that defines primordia flanking and central zones},
  author = {{L}avenus, {J}. and {G}oh, {T}. and {G}uyomarc'h, {S}. and {H}ill, {K}. and {L}ucas, {M}ika{\¨e}l and {V}oss, {U}. and {K}enobi, {K}. and {W}ilson, {M}. {H}. and {F}arcot, {E}. and {H}agen, {G}. and {G}uilfoyle, {T}. {J}. and {F}ukaki, {H}. and {L}aplaze, {L}aurent and {B}ennett, {M}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} large number of genes involved in lateral root ({LR}) organogenesis have been identified over the last decade using forward and reverse genetic approaches in {A}rabidopsis thaliana. {N}evertheless, how these genes interact to form a {LR} regulatory network largely remains to be elucidated. {I}n this study, we developed a time-delay correlation algorithm ({TDC}or) to infer the gene regulatory network ({GRN}) controlling {LR} primordium initiation and patterning in {A}rabidopsis from a time-series transcriptomic data set. {T}he predicted network topology links the very early-activated genes involved in {LR} initiation to later expressed cell identity markers through a multistep genetic cascade exhibiting both positive and negative feedback loops. {T}he predictions were tested for the key transcriptional regulator {AUXIN} {RESPONSE} {FACTOR}7 node, and over 70% of its targets were validated experimentally. {I}ntriguingly, the predicted {GRN} revealed a mutual inhibition between the {ARF}7 and {ARF}5 modules that would control an early bifurcation between two cell fates. {A}nalyses of the expression pattern of {ARF}7 and {ARF}5 targets suggest that this patterning mechanism controls flanking and central zone specification in {A}rabidopsis {LR} primordia.},
  keywords = {},
  booktitle = {},
  journal = {{P}lant {C}ell},
  volume = {27},
  numero = {5},
  pages = {1368--1388},
  ISSN = {1040-4651},
  year = {2015},
  DOI = {10.1105/tpc.114.132993},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064790},
}