@article{fdi:010064781,
  title = {{P}renatal hemoglobin levels and early cognitive and motor functions of one-year-old children},
  author = {{M}ireku, {M}. {O}. and {D}avidson, {L}. {L}. and {K}oura, {G}. {K}. and {O}uedraogo, {S}. and {B}oivin, {M}. {J}. and {X}iong, {X}. and {A}ccrombessi, {M}. {M}. {K}. and {M}assougbodji, {A}. and {C}ot, {M}ichel and {B}odeau-{L}ivinec, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{OBJECTIVE}: {T}o explore the relationship between prenatal hemoglobin ({H}b) concentration and infant cognitive and motor functions. {METHODS}: {O}ur prospective cohort study included 1-year-old children born to women enrolled at their first antenatal care ({ANC}) visit in {A}llada, {B}enin, before 29 weeks of pregnancy, within a trial comparing the efficacy of sulfadoxine-pyrimethamine and mefloquine. {H}b concentrations of pregnant women were determined from venous blood samples collected at first and second {ANC} visits of at least 1-month interval and at delivery. {W}omen were prescribed oral iron, folic acid, and anthelminthics after the first {ANC} visit. {A} total of 636 children (76.8% of eligible children) were assessed by trained research nurses for cognitive and motor functions by using the {M}ullen {S}cales of {E}arly {L}earning. {RESULTS}: {P}revalence of anemia ({H}b, 110 g/{L}) decreased from 67.0% at first {ANC} visit (mean gestational age [{SD}], 22.1 [4.0] weeks) to 38.4% at delivery. {M}ean ({SD}) {H}b concentrations increased from 103.7 (12.3) at first {ANC} visit to 112.4 (14.1) at delivery. {W}e observed a significant negative quadratic relationship between infant gross motor ({GM}) function and {H}b concentration at first and second {ANC} visits. {T}hus, infant {GM} scores increased sharply with increasing maternal {H}b concentration until 90 g/{L} where increasing {GM} was mild, and began to decline after 110 g/{L}. {CONCLUSIONS}: {T}here appears to be an {H}b concentration range that may be optimal for {GM} function of 1-year-old children. {T}his may reflect the importance of physiologic hemodilution, which occurs after the second trimester until 34 weeks of gestation.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}ediatrics},
  volume = {136},
  numero = {1},
  pages = {{E}76--{E}83},
  ISSN = {0031-4005},
  year = {2015},
  DOI = {10.1542/peds.2015-0491},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064781},
}